1-[2-(1-piperidinyl)phenyl]thiourea | 131679-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[2-(1-piperidinyl)phenyl]thiourea
• 英文别名: 1-(2-piperidinophenyl)thiourea；(2-piperidin-1-ylphenyl)thiourea
• CAS: 131679-26-0
• 化学式: C₁₂H₁₇N₃S
• mdl: MFCD16873309
• 分子量: 235.353
• InChiKey: JFXFQLTTXMZHBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[2-(1-piperidinyl)phenyl]thiourea 、 碘甲烷 在 Hg 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以to give 2-methyl-1-(2-piperidinophenyl)-2-thiopseudourea hydroiodide (m.p. 160°-162° C.)的产率得到2-methyl-1-(2-piperidinophenyl)-2-thiopseudourea hydroiodide
  参考文献：
  名称：

  Phenylamidine and phenylguanidine derivatives and their use as

  摘要：

  式I的化合物及其盐，其中n=0或1，R1和R2均为脂肪族或环烷基，或NR1R2为可选择取代的杂环环，R3为烷基，环烷基或可选择取代的氨基，R5为脂肪基，R6为H，可选择取代的脂肪基或环烷基，或R3和R5与它们所连接的氮和碳原子共同形成可选择取代的杂环环，或R5和R6与它们所连接的氮共同形成可选择取代的杂环环，或R7为可选择取代的烷基，烷氧基，烷基硫醚基，烷基磺酰基，烷氧羰基，三氟甲基或氰基，具有降糖剂的用途。

  公开号：

  US05223498A1

文献信息

• OPIOID RECEPTOR MODULATORS AND USE THEREOF
  申请人：National Health Research Institutes

  公开号：US20170056377A1

  公开（公告）日：2017-03-02

  Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.

  揭示了一种体外筛选方法，用于识别μ-阿片受体的拮抗剂-激动剂异位调节剂，并揭示了一种体内方法，用于确认测试化合物是否为μ-阿片受体的这种调节剂。还揭示了一种使用式（I）化合物和含有该化合物的药物组合物治疗阿片受体相关疾病的方法。
• Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
  申请人：——

  公开号：US20020042097A1

  公开（公告）日：2002-04-11

  Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallyglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.

  本发明揭示了制备含有氨基酸类似物的修饰多肽的方法。本发明进一步提供了通过本发明的方法生产的纯化的二氢叶酸还原酶多肽，其中甲硫氨酸残基已被替换为同烯基甘氨酸、同丙炔基甘氨酸、正异戊氨酸、正异癸氨酸、顺-十四烷基甘氨酸、反-十四烷基甘氨酸、2-氨基庚酸、2-丁炔基甘氨酸和烯丙基甘氨酸。
• OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES
  申请人：Tirrell David A.

  公开号：US20080160609A1

  公开（公告）日：2008-07-03

  Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.

  本发明揭示了一种生产含有氨基酸类似物的改性多肽的方法。本发明进一步提供了经本发明方法生产的纯化的脱氢叶酸还原酶多肽，其中甲硫氨酸残基已被替换为同丙烯基甘氨酸，同丙炔基甘氨酸，正戊氨酸，正亮氨酸，顺-十四烯基甘氨酸，反-十四烯基甘氨酸，2-氨基庚酸，2-丁炔基甘氨酸和丙烯基甘氨酸。
• Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them
  申请人：The Boots Company PLC

  公开号：EP0385038A1

  公开（公告）日：1990-09-05

  Compounds of formula I and their salts in which n = 0 or 1, R1 and R2 are each aliphatic or cycloalkyl or NR1 R2 is an optionally substituted heterocyclic ring, R3 is alkyl, cycloalkyl or optionally substituted amino, R5 is an aliphatic group, R6 is H, an optionally substituted aliphatic group or a cycloalkyl group, or R3 and R5 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R5 and R6 together with the nitrogen to which they are attached form a heterocyclic ring optionally substituted by alkyl and R7 is optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, trifluoromethyl or cyano have utility as hypoglycaemic agents.

  式 I 的化合物及其盐类 及其盐类，其中 n = 0 或 1，R1 和 R2 各为脂肪族或环烷基或 NR1 R2 为任选取代的杂环，R3 为烷基、环烷基或任选取代的氨基，R5 为脂肪族基团，R6 为 H、任选取代的脂肪族基团或环烷基基团、或 R3 和 R5 与它们所连接的氮原子和碳原子一起形成一个任选取代的杂环，或 R5 和 R6 与它们所连接的氮原子一起形成一个任选被烷基取代的杂环，R7 是任选取代的烷基、烷氧基、烷硫基、烷基亚砜基、烷基磺酰基、烷氧基羰基、三氟甲基或氰基。
• N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS
  申请人：G.D. SEARLE & CO.

  公开号：EP0555331A1

  公开（公告）日：1993-08-18