Chlorbis(4-methylphenyl)phenylmethan | 69239-35-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Chlorbis(4-methylphenyl)phenylmethan
• 英文别名: 4,4'dimethoxytrityl chloride；4,4'-dimethyl-trityl chloride；4,4'-Dimethyl-tritylchlorid；1-[Chloro-(4-methylphenyl)-phenylmethyl]-4-methylbenzene
• CAS: 69239-35-6
• 化学式: C₂₁H₁₉Cl
• 分子量: 306.835
• InChiKey: QKOPYEDBKRYHMW-UHFFFAOYSA-N

物化性质

• 熔点：
  108-109 °C
• 沸点：
  420.9±14.0 °C(Predicted)
• 密度：
  1.108±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  Chlorbis(4-methylphenyl)phenylmethan 在 sodium hydroxide 、 sodium tetrahydroborate 作用下， 生成 bis(p-tolyl)phenylmethane
  参考文献：
  名称：

  Substituent effect on the electrochemical oxidation of trityl anions

  摘要：

  DOI：

  10.1021/jo01323a020
• 作为产物：
  描述：

  bis(4-methylphenyl)phenylmethanol 在 乙酰氯 作用下， 以94%的产率得到Chlorbis(4-methylphenyl)phenylmethan
  参考文献：
  名称：

  Hellwinkel, Dieter; Fritsch, Helmut, Chemische Berichte, 1989, vol. 122, p. 2351 - 2360

  摘要：

  DOI：

文献信息

• Photolysis of Triarylmethylphosphonic Acids and Their Esters
  作者：Min Shi、Yoshiki Okamoto、Setsuo Takamuku

  DOI：10.1246/bcsj.63.453

  日期：1990.2

  Upon UV-irradiation in an alkaline alcohol solution, some triarylmethylphosphonic acids underwent C–P bond cleavage to give triarylmethanes and alkyl dihydrogenphosphates, while, in an acidic or a neutral alcohol solution, they afforded biaryls. Their dimethyl esters gave also biaryls and dimethyl [alkoxy(aryl)methyl]phosphonates, which were derived from the insertion of (dialkoxyphosphinyl)arylcarbenes

  在碱性醇溶液中紫外线照射后，一些三芳基甲基膦酸发生 C-P 键断裂，得到三芳基甲烷和磷酸二氢烷基酯，而在酸性或中性醇溶液中，它们得到联芳基化合物。它们的二甲酯也产生联芳基和 [烷氧基（芳基）甲基]膦酸二甲酯，它们源自（二烷氧基膦基）芳基卡宾插入醇的 OH 键。卡宾是通过光-α,α-消除膦酸酯的两个芳基而产生的。
• Multiplex analytical platform using molecular tags
  申请人：——

  公开号：US20030207300A1

  公开（公告）日：2003-11-06

  Compositions and methods are disclosed for detecting multiple target analytes, particularly polynucleotide target analytes. In accordance with one aspect of the invention, a template-dependent extension reaction is performed to generate detection probes, such that each detection probe has (i) at least one molecular tag attached by a cleavable linkage and (ii) either a capture moiety or a cleavage-inducing moiety attached. The template-dependent extension reaction may be carried out directly on a polynucleotide analyte to generate molecular tags, wherein the polynucleotide analyte serves as a template in the template-dependent extension reaction, or it may be carried out indirectly on an oligonucleotide label that, in turn, is attached to a binding moiety specific for an analyte of interest. In either case, a plurality of molecular tags are generated, after which they are separated and identified to determine the presence or absence or the quantity of the target analytes in a sample.

  本发明揭示了检测多种目标分析物的组合物和方法，特别是聚核苷酸目标分析物。根据本发明的一个方面，执行基于模板的延伸反应来生成检测探针，使得每个检测探针具有（i）至少一个通过可断裂的连接物连接的分子标签和（ii）连接了捕获基团或诱导断裂基团中的一种。基于模板的延伸反应可以直接在聚核苷酸分析物上进行，以生成分子标签，其中聚核苷酸分析物在基于模板的延伸反应中作为模板，或者间接地在寡核苷酸标签上进行，寡核苷酸标签反过来附着在特定于感兴趣的分析物的结合基团上。在任一情况下，生成多个分子标签，然后将它们分离和鉴定，以确定样品中目标分析物的存在或不存在或数量。
• METHOD FOR REPLICATING NUCLEIC ACIDS AND NOVEL UNNATURAL BASE PAIRS
  申请人：Hirao Ichiro

  公开号：US20100036111A1

  公开（公告）日：2010-02-11

  The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a deoxyribonucleoside 5′-triphosphate, in which the hydroxyl group of phosphoric acid at the γ-position is substituted with a group selected from the group consisting of an amino group, a methylamino group, a dimethylamino group, a mercapto group and a fluoro group, is used as a substrate during replication reaction. The novel artificial base pairs of the present invention are characterized in that 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) or an analog thereof forms a base pair with pyrrole-2-carbaldehyde (Pa) or an analog thereof.

  本发明涉及一种核酸复制方法和新型人工碱基对。本发明的核酸复制方法的特征在于，在复制反应过程中使用一种脱氧核苷酸5'-三磷酸作为底物，其中磷酸γ-位置的羟基被从以下群组中选择的一种群组所取代，所述群组包括氨基、甲基氨基、二甲基氨基、巯基和氟基。本发明的新型人工碱基对的特征在于，7-(2-噻吩基)-咪唑并[4,5-b]吡啶（Ds）或其类似物与吡咯-2-甲醛（Pa）或其类似物形成一对碱基。
• Synthetic Incorporation of Metal Complexes into Nucleic Acids and Peptides Directed toward Functionalized Molecules
  作者：Mitsuhiko Shionoya、Kentaro Tanaka

  DOI：10.1246/bcsj.73.1945

  日期：2000.9

  that o-phenylenediamine-type nucleoside forms a stable 2 : 1 square-planar complex with a PdII ion, providing an alternative DNA base pairing through metal complexation. Secondly, an efficient strategy for the liquid-phase synthesis of cyclic metallopeptides having a repeating Gly-L-Cys(terpyPtII) sequence, cyclo[-Gly-L-Cys(terpyPtII)-]nCln (n = 3, 4), has been developed. These cyclic metallopeptides

  描述了将金属配合物掺入核酸和肽的新合成方法。首先，合成了带有螯合剂核碱基（2-氨基苯酚、儿茶酚或邻苯二胺）的新型人工 β-C-核苷。这些人工核碱基是通过金属配位而不是天然 DNA 中的氢键引入的，用于替代碱基配对。1H NMR 和质谱研究清楚地表明，邻苯二胺型核苷与 PdII 离子形成稳定的 2:1 方形平面络合物，通过金属络合提供替代 DNA 碱基配对。其次，液相合成具有重复 Gly-L-Cys(terpyPtII) 序列 cyclo[-Gly-L-Cys(terpyPtII)-]nCln (n = 3, 4) 的环状金属肽的有效策略具有被开发。这些环状金属肽是通过环化相应的线性肽 H2[-Gly-L-Cys(terpyPtII)-]nOH·(CF3CO2)n+1 (n = 3, 4) 以中等产率获得的。前环六肽...
• Physiologically active peptide with between 147 and 162 amino acid residues
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0083777A1

  公开（公告）日：1983-07-20

  A novel physiologically active peptide represented by the following formula: (wherein B stands for a hydrogen atom or a methionyl group, Cys a cysteine residue, X1 5 to 9 amino acid residues, X2 one amino acid residue, and X3 138 to 148 amino acid residues), which is excellent in physiological activities such as antiviral action, cell proliferation inhibitive action and NK (natural killer) cell activity enhancing action.

  一种新型生理活性肽，由下式表示：（其中 B 代表氢原子或蛋酰基，Cys 代表半胱氨酸残基，X1 代表 5 至 9 个氨基酸残基，X2 代表 1 个氨基酸残基，X3 代表 138 至 148 个氨基酸残基），具有优异的生理活性，如抗病毒作用、抑制细胞增殖作用和增强 NK（自然杀伤）细胞活性作用。