毒理性
实验中，小鼠口服了以下物质：单独使用环丙沙星（50毫克/千克），单独使用铁化合物（硫酸亚铁、柠檬酸亚铁钠或焦磷酸铁；50毫克元素铁/千克），环丙沙星与每种铁化合物合用，或者环丙沙星与每种铁化合物以及抗坏血酸（250毫克/千克）联合使用。当与环丙沙星一同给予硫酸亚铁、柠檬酸亚铁钠或焦磷酸铁时，环丙沙星的最高血清浓度显著降低（P<0.01），从1.15+/-0.11微克/毫升（仅环丙沙星）分别降至0.17+/-0.01、0.27+/-0.01或0.28+/-0.02微克/毫升。添加抗坏血酸并不影响每种铁化合物对环丙沙星吸收的抑制效果。环丙沙星对每种铁化合物给药后血清铁水平的波动没有影响。添加抗坏血酸显著增强了柠檬酸亚铁钠给药后血清铁浓度的增加（P<0.01），从270+/-6微克/分升增加到463+/-11微克/分升，而仅柠檬酸亚铁钠给药后的增加从248+/-8微克/分升增加到394+/-18微克/分升。抗坏血酸还显著增加了焦磷酸铁给药后血清铁浓度（P<0.01），从261+/-16微克/分升增加到360+/-12微克/分升，尽管它对硫酸亚铁给药后的水平没有影响。
...Mice were treated orally with ciprofloxacin (50 mg/kg) alone, the iron compound (ferrous sulphate, sodium ferrous citrate or ferric pyrophosphate; 50 mg elemental iron/kg) alone, ciprofloxacin with each iron compound or ciprofloxacin in combination with each iron compound and ascorbic acid (250 mg/kg). The maximum serum concentration of ciprofloxacin was significantly (P<0.01) reduced from 1.15+/-0.11 ug/mL (ciprofloxacin alone) to 0.17+/-0.01, 0.27+/-0.01 or 0.28+/-0.02 ug/mL, respectively, when ferrous sulphate, sodium ferrous citrate or ferric pyrophosphate was administered along with ciprofloxacin. The addition of ascorbic acid did not affect the inhibitory effects of each iron compound on the absorption of ciprofloxacin. Ciprofloxacin did not affect the variation of serum iron levels after administration of each iron compound. The addition of ascorbic acid significantly (P<0.01) enhanced the increase in serum iron concentration after administration of sodium ferrous citrate, showing an increase from 270+/-6 ug/dL to 463+/-11 ug/dL compared with an increase from 248+/-8 ug/dL to 394+/-18 ug/dL after administration of sodium ferrous citrate alone. Ascorbic acid also caused a significant (P<0.01) increase in serum iron concentration from 261+/-16 ug/dL to 360+/-12 ug/dL after administration of ferric pyrophosphate, although it did not affect the levels after ferrous sulphate administration.
来源:Hazardous Substances Data Bank (HSDB)
