1,3,5-trimethyl-4,5-dihydro-1H-pyrazole | 1571-12-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 1,3,5-trimethyl-4,5-dihydro-1H-pyrazole
• 英文别名: 1,3,5-Trimethyl-Δ²-pyrazolin；1,3,5-Trimethyl-pyrazol-2-in；1,3,5-Trimethylpyrazolin；2-Pyrazoline, 1,3,5-trimethyl；2,3,5-trimethyl-3,4-dihydropyrazole
• CAS: 1571-12-6
• 化学式: C₆H₁₂N₂
• 分子量: 112.175
• InChiKey: RLPGNQZLVNPBIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3,5-trimethyl-4,5-dihydro-1H-pyrazole 、 苯甲腈 N-氧化物 以40%的产率得到
  参考文献：
  名称：

  GIBERT J.-P.; PETRUS P.; PETRUS F., J. HETEROCYCL. CHEM., 1979, 16, NO 2, 311-320

  摘要：

  DOI：

文献信息

• [EN] TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS<br/>[FR] COMPOSÉS DE TRIAZOLOPYRIDINE EN TANT QU'INHIBITEURS DE KINASE PIM
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2012154274A1

  公开（公告）日：2012-11-15

  Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

  式I的化合物：其中R1、R2、R3、R4和R10的含义如规范中所述，在通过PIM-1和/或PIM-2和/或PIM-3激酶介导的疾病治疗中有用的受体酪氨酸激酶抑制剂。
• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20180083196A1

  公开（公告）日：2018-03-22

  A condensed cyclic compound and an organic light-emitting device including the same, the condensed cyclic compound being represented by Formula 1:

  一种紧凑的环状化合物以及包括该化合物的有机发光器件，所述紧凑的环状化合物由公式1表示：
• TELOMERASE INHIBITORS AND A METHOD FOR THE PREPARATION THEREOF
  申请人：UCHREZHDENIE KHIMICHESKIJJ FAKUL'TET GOSUDARSTVENNOE UCHEBNO-NAUCHNOE

  公开号：US20130109861A1

  公开（公告）日：2013-05-02

  The invention relates to the field of organic and medicinal chemistry, and molecular biology, and concerns a method for the preparation of a new class of telomerase-inhibiting compounds, which can be utilized for studying telomerases and catalytic sub-units of telomerases, and reverse transcriptases, and foe studying and treating neoplastic and viral diseases. Telomerase-inhibiting coordination compounds of derivatives of imidazol-4-one are characterized by general formula

  本发明涉及有机化学、药物化学和分子生物学领域，涉及一种制备新型端粒酶抑制剂化合物的方法，可用于研究端粒酶和催化亚单位，以及反转录酶，用于研究和治疗肿瘤和病毒性疾病。咪唑-4-酮衍生物的端粒酶抑制配位化合物的一般式如下：
• SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID-RELATED ORPHAN RECEPTOR
  申请人：Glaxo Group Limited

  公开号：US20150361039A1

  公开（公告）日：2015-12-17

  The present invention is directed to novel retinoid-related orphan receptor gamma (RORγ) modulators, processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORγ.

  本发明涉及新型视黄醇相关孤儿受体γ（RORγ）调节剂，其制备过程，含有这些调节剂的药物组合物，以及它们在治疗由RORγ介导的炎症，代谢和自身免疫性疾病中的应用。
• DIARYL-AZOLE COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3135114A1

  公开（公告）日：2017-03-01

  To provide a diaryl-azole compound represented by formula (1) having an excellent controlling effect against arthropod pests, a control agent having an excellent controlling effect against arthropod pests, and a method for controlling arthropod pests in which the control agent is used. R1-3: C1-6 chain hydrocarbon, etc.; p: 0-3; q: 0-4; n: 0-2; X: N, CH, etc.; Ar: phenyl, 5-6-member aromatic heterocyclic ring; G: C1-6 chain hydrocarbon etc.; Het: formulas (H1) (H2) (H3)

  提供一种对节肢动物害虫具有极佳防治效果的式 (1) 所代表的二芳基唑化合物、一种对节肢动物害虫具有极佳防治效果的防治剂以及一种使用该防治剂防治节肢动物害虫的方法。R1-3:C1-6链烃等；p：0-3；q：0-4；n：0-2；X：N、CH等；Ar：苯基、5-6元芳香杂环；G：C1-6链烃等；Het：式（H1）（H2）（H3)