methyl(phenyl)vinylsilylacetic acid | 1269600-99-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: methyl(phenyl)vinylsilylacetic acid
• 英文别名: 2-(Ethenyl-methyl-phenylsilyl)acetic acid
• CAS: 1269600-99-8
• 化学式: C₁₁H₁₄O₂Si
• 分子量: 206.316
• InChiKey: MTPUSUKDSFIXQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl(phenyl)vinylsilylacetic acid 在 potassium hydroxide 作用下， 以 甲醇 、 乙二醇二甲醚 为溶剂， 以62%的产率得到1,2-bis[methyl(vinyl)phenylsilyl]ethane
  参考文献：
  名称：

  Electrochemical Synthesis of 1,2-Disilylethanes from α-Silylacetic Acids

  摘要：

  The synthesis of 1,2-disilylethanes [R1R2R3Si-(CH2)(2)SiR1R2R3] is usually conducted by using noble metal reagents or catalysts. This work describes a new electrochemical synthetic method for their preparation in good yields by oxidation of alpha-silylacetic acids at Pt anodes (Kolbe electrolysis). Most of the reported synthesized 1,2-disilylethanes in this work are unknown.

  DOI：

  10.1021/jo200254z
• 作为产物：
  描述：

  生成 methyl(phenyl)vinylsilylacetic acid
  参考文献：
  名称：

  Electrochemical Synthesis of 1,2-Disilylethanes from α-Silylacetic Acids

  摘要：

  The synthesis of 1,2-disilylethanes [R1R2R3Si-(CH2)(2)SiR1R2R3] is usually conducted by using noble metal reagents or catalysts. This work describes a new electrochemical synthetic method for their preparation in good yields by oxidation of alpha-silylacetic acids at Pt anodes (Kolbe electrolysis). Most of the reported synthesized 1,2-disilylethanes in this work are unknown.

  DOI：

  10.1021/jo200254z

文献信息

• Synthesis of α-silylcarboxylic acids
  作者：Alex V. Shtelman、James Y. Becker

  DOI：10.1016/j.tet.2010.12.020

  日期：2011.2

  New alpha-silylacetic acids have been prepared following a general and convenient procedure of a one-pot reaction between trimethylsilylacetate and different chlorosilanes. New derivatives of diphenyl(methyl) silylacetic acid were prepared by a direct alkylation of its dianion with benzyl-, allyl-, and alkyl halides and trimethylchlorogermane to afford new alpha-silylcarboxylic acids. (C) 2010 Elsevier Ltd. All rights reserved.
• Electrochemical Synthesis of 1,2-Disilylethanes from α-Silylacetic Acids
  作者：Alex V. Shtelman、James Y. Becker

  DOI：10.1021/jo200254z

  日期：2011.6.3

  The synthesis of 1,2-disilylethanes [R1R2R3Si-(CH2)(2)SiR1R2R3] is usually conducted by using noble metal reagents or catalysts. This work describes a new electrochemical synthetic method for their preparation in good yields by oxidation of alpha-silylacetic acids at Pt anodes (Kolbe electrolysis). Most of the reported synthesized 1,2-disilylethanes in this work are unknown.