Cyclopentyl-bis(3-methoxyprop-1-ynyl)-non-1-en-4-yloxysilane | 819048-80-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Cyclopentyl-bis(3-methoxyprop-1-ynyl)-non-1-en-4-yloxysilane
• CAS: 819048-80-1
• 化学式: C₂₂H₃₆O₃Si
• 分子量: 376.612
• InChiKey: MDVCWIZVWHNPNF-UHFFFAOYSA-N

物化性质

• 沸点：
  421.4±55.0 °C(Predicted)
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Cyclopentyl-bis(3-methoxyprop-1-ynyl)-non-1-en-4-yloxysilane 、 壬-1,8-二烯-5-醇 在 sodium hydride 作用下， 以 正己烷 为溶剂， 反应 0.33h， 以66%的产率得到Cyclopentyl-(3-methoxyprop-1-ynyl)-nona-1,8-dien-5-yloxy-non-1-en-4-yloxysilane
  参考文献：
  名称：

  Efficient Synthesis of Alkynylsilyl Ethers and Silaketals via Base-Induced Alkynylsilane Alcoholysis

  摘要：

  The efficient silylation of alcohols with di- and trialkynylsilanes was achieved under base-catalyzed conditions to afford alkynyl silyl ethers and symmetrical alkynyl silaketals in good yield. A selective alcoholysis of dialkynyl silyl ethers to mixed silaketals was also demonstrated. These products served as substrates for enyne ring-closing metathesis and, consequently, as precursors to stereochemically defined 1,3-dienes.

  DOI：

  10.1021/jo048908l
• 作为产物：
  描述：

  环戊基三氯硅烷 在 正丁基锂 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.17h， 生成 Cyclopentyl-bis(3-methoxyprop-1-ynyl)-non-1-en-4-yloxysilane
  参考文献：
  名称：

  Efficient Synthesis of Alkynylsilyl Ethers and Silaketals via Base-Induced Alkynylsilane Alcoholysis

  摘要：

  The efficient silylation of alcohols with di- and trialkynylsilanes was achieved under base-catalyzed conditions to afford alkynyl silyl ethers and symmetrical alkynyl silaketals in good yield. A selective alcoholysis of dialkynyl silyl ethers to mixed silaketals was also demonstrated. These products served as substrates for enyne ring-closing metathesis and, consequently, as precursors to stereochemically defined 1,3-dienes.

  DOI：

  10.1021/jo048908l