1,3,4-Trimethylpiperidine | 62171-81-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,3,4-Trimethylpiperidine
• CAS: 62171-81-7
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: SGEACAMHETYOIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] PHENOXY BENZAMIDE COMPOUNDS WITH UTILITY IN THE TREATMENT OF TYPE 2 DIABETES AND OBESITY<br/>[FR] COMPOSES DE PHENOXY BENZAMIDE AYANT UNE UTILITE DANS LE TRAITEMENT DU DIABETE DE TYPE 2 ET DE L'OBESITE
  申请人：ASTRAZENECA AB

  公开号：WO2006040528A1

  公开（公告）日：2006-04-20

  Compounds of Formula: (I); wherein: R1 is methoxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5 is hydrogen or (1-4C)alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  化合物的分子式为：(I)；其中：R1为甲氧甲基；R2选择自-C(O)NR4R5、SO2NR4R5、S(O)pR4和HET-2；HET-1为5-或6-成员的、可选择性取代的C-连接杂芳基环；HET-2为4-、5-或6-成员的、C-或N-连接的可选择性取代的杂环烷基环；R3选择自卤素、氟甲基、二氟甲基、三氟甲基、甲基、甲氧基和氰基；R4选择自氢、可选择性取代的(1-4C)烷基和HET-2；R5为氢或(1-4C)烷基；或者R4和R5连同它们连接的氮原子可以形成由HET-3定义的杂环烷基环系统；HET-3例如为可选择性取代的N-连接、4、5或6成员的、饱和或部分不饱和的杂环烷基环；p为（每次独立）0、1或2；m为0或1；n为0、1或2；条件是当m为0时，n为1或2；或其盐、前药或溶剂化合物。描述了它们作为GLK激活剂的用途、含有它们的药物组合物以及它们的制备方法。
• Nitrogen-containing heterocyclic compound and use thereof
  申请人：Ikeura Yoshinori

  公开号：US20090156572A1

  公开（公告）日：2009-06-18

  The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R 1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R 2 is an optionally halogenated C 1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

  本发明涉及一种由下式表示的化合物：其中环A是含氮杂环，可选择地进一步具有取代基，环B是芳香环，可选择地具有取代基，环C是环状基团，可选择地具有取代基，R1是氢原子，一个碳氢基团，可选择地具有取代基，酰基，一个杂环基团，可选择地具有取代基或一个氨基团，可选择地具有取代基，R2是可选择卤代的C1-6烷基基团，m和n分别是0到5的整数，m+n是2到5的整数，是单键或双键，或其盐等。由于该化合物具有优越的催吐肽受体拮抗作用，可用作预防或治疗多种疾病的药物，如下尿道疾病、胃肠道疾病、中枢神经系统疾病等。
• 2-Substituted Pyridines, Processes for their Preparation and Their Use for Controlling Harmful Fungi
  申请人：Rheinheimer Joachim

  公开号：US20070259919A1

  公开（公告）日：2007-11-08

  The invention relates to 2-substituted pyridines of the formula I in which the index n and the substituents R 1 to R 4 and L are as defined in the description and in each case one of the two ring members X 1 , X 2 is N, the other is C—H or C-halogen; Y is a group —CH—R 1 —, —N—R 1 —, —O— or —S— and is five- or six-membered hetaryl comprising 1 to 3 heteroatoms selected from the group consisting of O, N and S or is phenyl, and to processes for their preparation, intermediates for their preparation, pesticidal compositions and methods for controlling harmful fungi and animal pests using the compounds according to the invention.

  该发明涉及公式I中的2-取代吡啶，其中指数n和取代基R1至R4和L如描述中所定义，并且每种情况下两个环成员X1、X2中的一个是N，另一个是C—H或C-卤素；Y是一个基团—CH—R1—，—N—R1—，—O—或—S—，并且是包含1至3个来自O、N和S的杂原子的五元或六元杂芳基，或是苯基；以及它们的制备方法、制备中间体、杀虫剂组合物和使用根据该发明的化合物控制有害真菌和动物害虫的方法。
• [EN] QUINOLINYLOXYPHENYLSULFONAMIDES<br/>[FR] QUINOLINYLOXYPHÉNYLSULFONAMIDES
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2011045084A1

  公开（公告）日：2011-04-21

  The present invention relates to quinolinyloxyphenylsulfonamides and stereoisomeric forms, solvates, hydrates and/or pharmaceutically acceptable salts of these quinolinyloxyphenylsulfonamide compounds as well as pharmaceutical compositions containing at least one of these compounds together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said quinolinyloxyphenylsulfonamides are useful for prophylaxsis, treatment and/or after-treatment of hyperproliferative disorders, such as cancer, tumors and particularly cancer metastases.

  本发明涉及喹啉氧基苯磺酰胺及其立体异构体形式、溶剂化物、水合物和/或这些喹啉氧基苯磺酰胺化合物的药学上可接受的盐，以及含有至少一种这些化合物和至少一种药学上可接受的载体、赋形剂和/或稀释剂的制剂。所述喹啉氧基苯磺酰胺对于预防、治疗和/或后治疗增生性疾病，如癌症、肿瘤，特别是癌症转移，具有有用的作用。
• Quinolinyloxyphenylsulfonamides
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2311809A1

  公开（公告）日：2011-04-20

  The present invention relates to quinolinyloxyphenylsulfonamides and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these quinolinyloxyphenylsulfonamide compounds as well as pharmaceutical compositions containing at least one of these compounds together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said quinolinyloxyphenylsulfonamides are useful for prophylaxsis, treatment and/or after-treatment of hyperproliferative disorders, such as cancer, tumors and particularly cancer metastases.

  本发明涉及喹啉氧基苯磺酰胺及其立体异构体、前药、溶剂化物、水合物和/或药学上可接受的盐，以及包含至少一种这些化合物和至少一种药学上可接受的载体、赋形剂和/或稀释剂的制药组合物。所述喹啉氧基苯磺酰胺对于预防、治疗和/或后治疗增殖过度的疾病，如癌症、肿瘤，尤其是癌症转移，是有用的。