N-(3-bromophenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine | 929395-97-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: N-(3-bromophenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine
• 英文别名: (3-bromo-phenyl)-(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-amine；N-(3-bromophenyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine
• CAS: 929395-97-1
• 化学式: C₁₆H₁₄BrN₃S
• 分子量: 360.277
• InChiKey: NVWVZLNJWRDTNJ-UHFFFAOYSA-N

物化性质

• 沸点：
  526.1±50.0 °C(predicted)
• 密度：
  1.576±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩 在 溶剂黄146 作用下， 78.0~90.0 ℃ 、1.38 MPa 条件下， 反应 0.25h， 生成 N-(3-bromophenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  A Microwave-Enhanced Synthesis and Biological Evaluation of N-Aryl‑5,6,7,8‑tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amines

  摘要：

  DOI：

  10.21577/0103-5053.20190044

文献信息

• TRICYCLIC BENZO[4,5]THIENO-[2,3-D]PYRIMIDINE-4-YL-AMIN DERIVATIVES, THEIR SALTS, PROCESS FOR PRODUCING THE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：Bánhegyi Pèter

  公开号：US20110015214A1

  公开（公告）日：2011-01-20

  The invention relates to novel tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, as well as their pharmaceutically acceptable salts. The subject of the invention too the process for producing the compounds and their use as a pharmaceutically active agent and as pharmaceutical compositions for prophylaxis and/or treatment of proliferative diseases such as cancer.

  该发明涉及新颖的三环苯并[4,5]噻吩-[2,3-d]嘧啶-4-基-氨基衍生物，以及它们的药学上可接受的盐。该发明还涉及制备这些化合物的方法，以及它们作为药用活性剂和用于预防和/或治疗增殖性疾病如癌症的药物组合物。
• [EN] TRICYCLIC BENZO[4,5]THIENO-[2,3-D]PYRIMIDINE-4-YL-AMIN DERIVATIVES, THEIR SALTS, PROCESS FOR PRODUCING THE COMPOUNDS AND THEIR PHARMACEUTICAL USE<br/>[FR] DÉRIVÉS TRICYCLIQUES DE BENZO[4,5]THIÉNO-[2,3-D]PYRIMIDIN-4-YLAMINE, LEURS SELS, PROCÉDÉ DE FABRICATION DES COMPOSÉS ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：VICHEM CHEMIE KUTATO KFT

  公开号：WO2009104026A1

  公开（公告）日：2009-08-27

  The invention relates to novel tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, as well as their pharmaceutically acceptable salts. The subject of the invention too the process for producing the compounds and their use as a pharmaceutically active agent and as pharmaceutical compositions for prophylaxis and/or treatment of proliferative diseases such as cancer.

  本发明涉及新型三环苯并[4,5]噻吩-[2,3-d]嘧啶-4-基氨基衍生物，以及其药学上可接受的盐。本发明还涉及生产该化合物的方法，以及将其用作药学活性剂和制备用于预防和/或治疗增殖性疾病如癌症的药物组合物。
• TRICYCLIC BENZOÝ4,5¨THIENO-Ý2,3-D¨PYRIMIDINE-4-YL-AMIN DERIVATIVES, THEIR SALTS, PROCESS FOR PRODUCING THE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：Vichem Chemie Kutató KFT

  公开号：EP2257554A1

  公开（公告）日：2010-12-08
• US8802849B2
  申请人：——

  公开号：US8802849B2

  公开（公告）日：2014-08-12
• A Microwave-Enhanced Synthesis and Biological Evaluation of N-Aryl‑5,6,7,8‑tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amines
  作者：Qing Han、Zijian Yin、Jingjiao Sui、Qingming Wang、Yaquan Sun

  DOI：10.21577/0103-5053.20190044

  日期：——