2,5-Dimethyl-3-ethylthiophene | 55735-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2,5-Dimethyl-3-ethylthiophene
• 英文别名: 3-Ethyl-2,5-dimethylthiophen；3-ethyl-2,5-dimethyl-thiophene；3-Aethyl-2,5-dimethyl-thiophen；Thiophene, 3-ethyl-2,5-dimethyl；3-ethyl-2,5-dimethylthiophene
• CAS: 55735-23-4
• 化学式: C₈H₁₂S
• 分子量: 140.249
• InChiKey: HNWCHVKZEZCJMN-UHFFFAOYSA-N

物化性质

• 熔点：
  -56.9°C (estimate)
• 沸点：
  181.79°C (estimate)
• 密度：
  0.9967 (estimate)
• 保留指数：
  1056

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-Dimethyl-3-ethylthiophene 在 sodium hypochlorite 、 盐酸羟胺 、 sodium acetate 、 四氯化锡 作用下， 以 四氯化碳 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 55.33h， 生成 3-(4-Ethyl-2,5-dimethyl-thiophen-3-yl)-5-phenyl-4,5-dihydro-isoxazole
  参考文献：
  名称：

  噻吩系列的一氧化氮：1,3-偶极环加成反应中空间因素对稳定性和反应性的影响

  摘要：

  DOI：

  10.1007/bf00479334
• 作为产物：
  描述：

  2,5-二甲基-3-乙酰基噻吩 在 盐酸 、 amalgamated zinc 、 苯 作用下， 生成 2,5-Dimethyl-3-ethylthiophene
  参考文献：
  名称：

  Buu-Hoi; Nguyen-Hoan, Recueil des Travaux Chimiques des Pays-Bas, 1948, vol. 67, p. 309,325

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES<br/>[FR] INHIBITEURS DE GLYCOSYL TRANSFÉRASES BACTÉRIENNES
  申请人：HARVARD COLLEGE

  公开号：WO2016191658A1

  公开（公告）日：2016-12-01

  Described herein are compounds of Formula (I'), Formula (IA), Formulae (I)-(VII), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrug sthereof. The invention also provides pharmaceutical compositions of the compounds for human and veterinary use. Compounds of the present invention are useful for inhibiting bacterial growth and therefore are useful in treating and/or preventing bacterial infections. Methods of using the compounds for treating and/or preventing a bacterial infection in a subject are also described.

  本文描述了式(I')、式(IA)、式(I)-(VII)的化合物，以及这些化合物的药用盐、溶剂合物、水合物、多型体、共晶体、互变异构体、立体异构体、同位素标记衍生物和前药。本发明还提供了这些化合物的用于人类和兽医用途的药物组合物。本发明的化合物对抑制细菌生长有用，因此在治疗和/或预防细菌感染方面具有用途。还描述了使用这些化合物治疗和/或预防受试者细菌感染的方法。
• [EN] PURIFICATION OF CIS-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE VIA EXTRACTIVE DISTILLATION<br/>[FR] PURIFICATION DU CIS-1,1,1,4,4,4-HEXAFLUORO-2-BUTÈNE PAR DISTILLATION EXTRACTRICE
  申请人：DU PONT

  公开号：WO2012079011A1

  公开（公告）日：2012-06-14

  A process for separating cis-1,1,1,4,4,4-hexafluoro-2-butene from a first mixture comprising cis-1,1,1,4,4,4-hexafluoro-2-butene and at least one chlorofluoroolefin is disclosed. The process involves the steps of contacting said first mixture with at least one extractive agent, to form a second mixture, distilling said second mixture; and recovering cis-1,1,1,4,4,4-hexafluoro-2-butene substantially free of chlorofluoroolefin.

  本发明公开了一种从含有顺-1,1,1,4,4,4-六氟-2-丁烯和至少一种氯氟烯的第一混合物中分离顺-1,1,1,4,4,4-六氟-2-丁烯的方法。该过程包括以下步骤：将该第一混合物与至少一种萃取剂接触以形成第二混合物，蒸馏该第二混合物，并回收基本无氯氟烯的顺-1,1,1,4,4,4-六氟-2-丁烯。
• Composite material of hole-blocking polymer and electron-injection/electron-transport conjugated polymer grafted with crown ether into which metal ion is intercalated, and uses thereof in OLED and organic solar cell
  申请人：CHEN SHOW-AN

  公开号：US20130140527A1

  公开（公告）日：2013-06-06

  An water/alcohol soluble electron-injection/hole-blocking composite layer contains a conjugated polymer grafted with a side chain crown ether and with pseudo-metallic state of metal-ion stabilized by the crown ether (to reduce electron-injection barrier and facilitate electron transport), and a polymer with hole-blocking function. This composite layer is able to improve the performance of an organic light emitting diode with oxygen- and moisture-stable cathode (such as Al and Au), and the performance of an organic solar cell.

  一种水/醇可溶的电子注入/空穴阻挡复合层包含一个共轭聚合物，该聚合物搭载一个侧链冠醚，并通过冠醚稳定了金属离子的伪金属态（以降低电子注入屏障和促进电子传输），以及一个具有空穴阻挡功能的聚合物。该复合层能够提高有氧和湿度稳定的阴极（如铝和金）的有机发光二极管和有机太阳能电池的性能。
• CHEMICAL COMPOUNDS
  申请人：Pitterna Thomas

  公开号：US20100311582A1

  公开（公告）日：2010-12-09

  A compound of the formula (I) where, for example, W, X and Y are each CH; R 1 and R 6 , independently of each other, are for example, selected from the group consisting of H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C3-C8-cycloalkyl, R 7 C(═O), and a ring system; provided that at least one of R 1 and R 6 is a —C2-C6-alkenylthio-C1-C6-alkyl, —C1-C6-alkoxy-C(═O)NRx-C1-C6-alkyl, —partially or fully unsaturated ring system containing in at least one ring in the ring system at least one hetero atom selected from N, O and S, which ring system is bound (i.e. through the N bonded to R 1 and R 6 in formula I) either directly or via a a C1-C6-alkylene group to the remainder of the compound, —partially or fully unsaturated ring system containing a ring that is bound to the remainder of the compound (i.e. through the N bonded to R 1 and R 6 in formula I) via a C1-C6-alkylene group, which group contains at least one hetero atom and/or heteroatom group selected from N, O, S, SO, SO 2 , and C(=0), —a ring system having a 5- to 14-membered bicylic ring which may be unsubstituted or be substituted with 1, 2 or 3, independently of one another, radicals selected from halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy, or —(C3-C8-cyloalkyl)thio-C1-C6-alkyl; R 2 is, for example, H, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy or C1-C6-alkoxy-C1-C6-alkoxy, and/or salts thereof; and their use as pesticidal agents.

  化合物的公式（I），其中，例如，W、X和Y都是CH；R1和R6彼此独立，例如，从H、C1-C6-烷基、C2-C6-烯基、C2-C6-炔基、C1-C6-烷氧基、C3-C8-环烷基、R7C（═O）和环系组成的群中选择；前提是R1和R6中至少有一个是-C2-C6-烯基硫基-C1-C6-烷基，-C1-C6-烷氧基-C（═O）NRx-C1-C6-烷基，部分或完全不饱和的环系，其中在环系中至少有一个环中含有N、O和S中选择的至少一个杂原子，该环系通过式I中与R1和R6结合的N直接或通过C1-C6-烷基链与化合物的其余部分结合，部分或完全不饱和的环系，其中有一个环通过C1-C6-烷基链与化合物的其余部分结合，该链含有至少一个N、O、S、SO、SO2和C（=0）中选择的杂原子和/或杂原子基，具有5-至14-成员的双环环系，可以是未取代的或被1、2或3个彼此独立的基团（选择自卤素、C1-C6-烷基、C1-C6-卤代烷基、C1-C6-烷氧基和C1-C6-卤代烷氧基）取代的；R2，例如，是H、卤素、C1-C6-烷基、C1-C6-卤代烷基、C1-C6-烷氧基、C1-C6-卤代烷氧基或C1-C6-烷氧基-C1-C6-烷氧基，和/或其盐；以及它们作为杀虫剂的用途。
• Marking
  申请人：COURTAULDS PLC

  公开号：EP0279600A1

  公开（公告）日：1988-08-24

  A marking comprises a layer, preferably of film-­forming material, which contains a photochromic compound. The photochromic compound is capable of changing colour when exposed to uv light, but can be converted to a perman­ently non-photochromic compound, preferably by over-­exposure to uv light. An image is formed in the layer by converting the photochromic compound to a permanently non-photochromic compound in one or more selected areas. When the layer is subsequently viewed under uv light a colourless image of non-photochromic compound can be seen on a background of coloured photochromic compound.

  标记包括一层，最好是成膜材料，其中含有一种光致变色化合物。光致变色化合物在紫外光照射下能改变颜色，但最好在紫外光过度照射下能转化为永久性的非光致变色化合物。通过在一个或多个选定区域将光致变色化合物转化为永久性非光致变色化合物，在层中形成图像。随后在紫外光下观察该层时，可以看到在彩色光致变色化合物的背景上有一个无色的非光致变色化合物图像。