2,2-dibutyl-2-stanna-1,3-dithiane | 7191-32-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 英文名称: 2,2-dibutyl-2-stanna-1,3-dithiane
• CAS: 7191-32-4
• 化学式: C₁₁H₂₄S₂Sn
• 分子量: 339.154
• InChiKey: GOTLNLSQOCQENN-UHFFFAOYSA-L

物化性质

• 熔点：
  63-64 °C
• 沸点：
  170 °C/0.5 mmHg

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,7-庚二酰氯 、 2,2-dibutyl-2-stanna-1,3-dithiane 以 氯仿 为溶剂， 反应 0.5h， 以48%的产率得到1,5-Dithiacyclododecane-6,12-dione
  参考文献：
  名称：

  Preparation of Macrocyclic Poly-thiolactones

  摘要：

  DOI：

  10.1055/s-1984-30757
• 作为产物：
  描述：

  1,3-丙二硫醇 、 二丁基二氯化锡 生成 2,2-dibutyl-2-stanna-1,3-dithiane
  参考文献：
  名称：

  SHANZER, A.;LIBMAN, J., SYNTHESIS, BRD, 1984, N 2, 140-141

  摘要：

  DOI：

文献信息

• Activation and synthetic applications of thiostannanes. Conversion of aldehydes and acetals into 1,3-dithianes with high chemodifferentiation
  作者：Tsuneo Sato、Enji Yoshida、Takamichi Kobayashi、Junzo Otera、Hitosi Nozaki

  DOI：10.1016/s0040-4039(00)80396-2

  日期：1988.1

  Novel method for transforming aldehydes and acetals into 1,3-dithianes has been achieved with the aid of organotin thioalkoxides and organotin triflates. Under these reaction conditions, various acid-sensitive groups are tolerated. Differentiation between aromatic or aliphatic aldehydes and acetals has been realized.

  借助于有机锡硫代醇盐和有机锡三氟甲磺酸酯，已经实现了将醛和乙缩醛转化为1，3-二硫杂环己烷的新方法。在这些反应条件下，可以耐受各种酸敏感性基团。已经实现了芳族或脂族醛与缩醛之间的区分。
• Differentiation between carbonyls and acetals in 1,3-dithiane and 1,3-dithiolane synthesis catalyzed by organotin triflates
  作者：Tsuneo Sato、Junzo Otera、Hitosi Nozaki

  DOI：10.1021/jo00070a038

  日期：1993.8

  Carbonyls and acetals are converted to 1,3-dithianes and -dithiolanes upon treatment with 2-stanna-1,3-dithianes and -dithiolanes under catalysis by organotin triflates. In these competition reactions, various types of carbonyls and acetals are differentiated. Aldehydes react preferentially over ketones, but the preference is completely reversed in the competition reactions between the corresponding acetals and ketals. The reactivity of aliphatic aldehydes is greater than that of the acetals of aliphatic aldehydes and ketones. Conversely, an aromatic acetal is more reactive than its parent aldehyde. In the competition between aromatic and aliphatic aldehydes, the reaction of the latter predominates. However, aromatic acetals react preferentially over aliphatic acetals. Ketones of different types are also differentiated. No such discrimination can be achieved by conventional methods. Organotin triflates are capable of detecting subtle differences in the reactivity of carbonyls and acetals. Such unique differentiation can be explained in terms of the dependence of the reaction path on the substrate: the reactions of carbonyls are initiated by coordination to tin, whereas the reactions of acetals proceed via oxocarbenium ion intermediates.
• Design and synthesis of a selective EP4-Receptor agonist. Part 1: discovery of 3,7-DithiaPGE1 derivatives and identification of Their ω chains
  作者：Toru Maruyama、Masaki Asada、Tai Shiraishi、Hiromu Egashira、Hideyuki Yoshida、Takayuki Maruyama、Shuichi Ohuchida、Hisao Nakai、Kigen Kondo、Masaaki Toda

  DOI：10.1016/s0968-0896(01)00351-0

  日期：2002.4

  Improvement of EP4-receptor selectivity and the agonist activity by introduction of heteroatoms into the a chain of PGE(1) was investigated. Among the compounds tested, 3,7-dithiaPGE(1) 4a exhibited good EP4-receptor selectivity and agonist activity. Further modification of the omega chain of 3,7-dithiaPGE(1) was performed to improve EP4-receptor selectivity and agonist activity. Of the compounds produced, 16-phenyl-omega-tetranor-3.7-dithiaPGE(1) 4p possessing moderate EP4-receptor selectivity and agonist activity. was identified as a new chemical lead for further optimization by modification of the aromatic moiety. (C) 2002 Elsevier Science Ltd. All rights reserved.
• SATO, TSUNEO;YOSHIDA, ENJI, KOBAYASHI TAKAMICHI;OTERA, JUNZO;NOZAKI, HITO+, TETRAHEDRON EDRON LETT., 29,(1988) N 32, C. 3971-3974
  作者：SATO, TSUNEO、YOSHIDA, ENJI, KOBAYASHI TAKAMICHI、OTERA, JUNZO、NOZAKI, HITO+

  DOI：——

  日期：——
• Preparation of Macrocyclic Poly-thiolactones
  作者：Abraham Shanzer、Jacqueline Libman

  DOI：10.1055/s-1984-30757

  日期：——