2-氨基-4-二甲基氨基-6-甲基-1,3,5-三嗪 | 21320-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 2-氨基-4-二甲基氨基-6-甲基-1,3,5-三嗪
• 中文别名: 2-氨基-4-二甲氨基-6-甲基-1,3,5-三嗪
• 英文名称: N²,N²-dimethyl-6-methyl-2,4-diamino-1,3,5-triazine
• 英文别名: 2-amino-4-dimethylamino-6-methyl-1,3,5-triazine；N,N,6-trimethyl-1,3,5-triazine-2,4-diamine；6,N,N'-trimethyl-[1,3,5]triazine-2,4-diamine；6,N²,N²-trimethyl-[1,3,5]triazine-2,4-diyldiamine；6,N²,N²-Trimethyl-[1,3,5]triazin-2,4-diyldiamin；2-amino-4-dimethylamino-6-methyl-s-triazine；2-N,2-N,6-trimethyl-1,3,5-triazine-2,4-diamine
• CAS: 21320-31-0
• 化学式: C₆H₁₁N₅
• mdl: MFCD00067864
• 分子量: 153.187
• InChiKey: DUAYDERMVQWIJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933699090

反应信息

• 作为反应物：
  描述：

  硝基脲 、 2-氨基-4-二甲基氨基-6-甲基-1,3,5-三嗪 在 硫酸 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以80%的产率得到[4-(Dimethylamino)-6-methyl-1,3,5-triazin-2-yl]urea
  参考文献：
  名称：

  Synthesis and properties of derivatives of sym-triazine. 5. Synthesis and mass spectrometric study of carbamide derivatives of sym-triazine

  摘要：

  DOI：

  10.1007/bf00761989

文献信息

• Copper-Catalyzed Tandem Reactions of 2-Amine-[1,3,5]triazines with Nitriles
  作者：Li-Yu Zhang、Chen Zhang、Tao Wang、Yu-Long Shi、Meng-Tao Ban、Dong-Mei Cui

  DOI：10.1021/acs.joc.8b02150

  日期：2019.1.18

  of 2-amine-[1,3,5]triazines and aryl nitriles for the synthesis of [1,2,4]triazolo[1,5-a][1,3,5]triazines via N–C bond formation and oxidative N–N coupling [oxidative 3 + 2 cyclization] is presented. A wide range of aryl nitriles, including electron-rich benzonitriles, electron-poor benzonitriles, 2-cyanothiophene, and 4-cyanopyridine, were all functionalized with 2-amine-[1,3,5]triazines. Furthermore

  铜催化的2-胺-[1,3,5]三嗪和芳基腈的分子间环化反应，通过N合成[1,2,4]三唑[1,5- a ] [1,3,5]三嗪介绍了–C键的形成和氧化性N–N偶联[氧化性3 + 2环化]。各种各样的芳基腈，包括富含电子的苯甲腈，贫电子的苯甲腈，2-氰基噻吩和4-氰基吡啶，都被2-胺-[1,3,5]三嗪官能化。此外，还证明了通过铜催化的苯乙腈的C-CN键裂解，使2-胺-[1,3,5]三嗪发生酰胺化。该反应以中等至令人满意的产率发生，并且耐受烷基或芳基取代的2-胺-[1,3,5]三嗪。苯胺，氨基吡啶和氨基嘧啶也提供了所需的产物。
• Synthesis of 2-Arylamino-1,3,5-triazines from 2-Aminotriazines with Aryl Halides via CuI-Catalyzed Ullmann Coupling Reaction
  作者：Dong-Mei Cui、Chen Zhang、Jin Li、Kong Wu、Wei Zhou、Hong Wang

  DOI：10.1055/s-0035-1561632

  日期：——

  An efficient copper-catalyzed synthesis of 2-arylamino-1,3,5-triazines from 2-aminotriazines with aryl halides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aryl iodides containing functionalities such as nitriles, ethers, amides, and halogens. Aryl bromides were also well tolerated.

  已开发出一种在温和条件下由 2-氨基三嗪与芳基卤化物有效合成 2-芳氨基-1,3,5-三嗪的方法。该反应以中等至良好的产率发生，并且可以耐受含有腈、醚、酰胺和卤素等官能团的芳基碘。芳基溴也具有良好的耐受性。
• Diversity-oriented synthesis of imidazo[1,2-<i>a</i>][1,3,5]triazine derivatives from 2-amine-[1,3,5]triazines with ketones
  作者：Wanqiu Zhao、Cheng Zhang、Pengzhen Zhong、Wei Zhou、Chen Zhang、Dong-Mei Cui

  DOI：10.1039/d1cc04294g

  日期：——

  An I2-mediated annulation of 2-amino[1,3,5]triazines and ketones for the synthesis of imidazo[1,2-a][1,3,5]triazines is presented. Electron rich, or electron poor acetophenone and heterocycle ketones, as well as propiophenone, are functionalized with 2-amino-[1,3,5]triazines. Another class of imidazo[1,2-a][1,3,5]triazines tethered with an additional 1,2-dicarbonyl motif through the combination of

  提出了用于合成咪唑并[1,2- a ][1,3,5]三嗪的I 2介导的2-氨基[1,3,5]三嗪和酮的环化。富电子或缺电子苯乙酮和杂环酮，以及苯丙酮，用 2-氨基-[1,3,5]三嗪官能化。另一类咪唑并[1,2- a ][1,3,5]三嗪通过环化和C-H官能化的组合与额外的1,2-二羰基基序相连，而不是通过改变反应条件获得。新方法实际上很简单，适用于克级。
• Compositions and Methods for Treating Metabolic Disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US20140193498A1

  公开（公告）日：2014-07-10

  Compositions and methods for improving the pharmacokinetics and reducing the risk of adverse events resulting from biguanide compound administration are provided, comprising administering delayed release formulations of such compounds having a lag phase release.

  本发明提供了用于改善双胍类化合物的药代动力学并减少由其使用导致的不良事件风险的组合物和方法，包括给予延迟释放配方的这种化合物，其具有滞后释放阶段。
• COMPOSITIONS FOR INHIBITION OF INSECT SENSING
  申请人：Zwiebel Laurence

  公开号：US20140242135A1

  公开（公告）日：2014-08-28

  In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及昆虫嗅觉受体的化学调节剂。具体地，提供了可以抑制空气传播昆虫（例如蚊子）的感觉（例如宿主定位）功能的化合物和组合物。还提供了使用这些剂的方法以及包含它们的文章。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。