2-氯-5,6,7,8-四氢-4H-噻吩并[2,3-d]氮杂烷 | 873015-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 中文名称: 2-氯-5,6,7,8-四氢-4H-噻吩并[2,3-d]氮杂烷
• 英文名称: 2-chloro-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine
• CAS: 873015-86-2
• 化学式: C₈H₁₀ClNS
• mdl: MFCD11044624
• 分子量: 187.693
• InChiKey: ZHIUIUIKCXHLKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted azepine derivatives as serotonin receptor modulators
  申请人：Bennani L. Youssef

  公开号：US20060003990A1

  公开（公告）日：2006-01-05

  The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

  本发明一般涉及一系列化合物，含有这些化合物的药物组合物，以及将这些化合物和组合物用作治疗剂。更具体地，本发明的化合物是六氢吲哚和八氢吲哚化合物。这些化合物是5-羟色胺受体（5-HT）配体，可用于治疗需要调节5-羟色胺受体（5-HT）活性的疾病、障碍和症状（例如焦虑、抑郁和肥胖）。
• Substituted Azepine Derivatives As Serotonin Receptor Modulators
  申请人：Bennani Youssef L.

  公开号：US20100190772A1

  公开（公告）日：2010-07-29

  The present invention generally relates to compounds and pharmaceutical compositions containing the compounds. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

  本发明通常涉及化合物和含有这些化合物的药物组合物。更具体地说，本发明的化合物是六氢吲哚并环己氮化吲哚和八氢吲哚并环己氮化吲哚化合物。这些化合物是血清素受体(5-HT)配体，可用于治疗希望调节血清素受体(5-HT)活性的疾病、障碍和病况(例如焦虑、抑郁和肥胖症)。
• SUBSTITUTED AZEPINE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS
  申请人：Athersys, Inc.

  公开号：EP1778243B1

  公开（公告）日：2012-10-31
• US7718647B2
  申请人：——

  公开号：US7718647B2

  公开（公告）日：2010-05-18
• [EN] SUBSTITUTED AZEPINE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS<br/>[FR] DERIVES D'AZEPINE SUBSTITUES UTILISES COMME MODULATEURS DES RECEPTEURS DE LA SEROTONINE
  申请人：ATHERSYS INC

  公开号：WO2006004931A2

  公开（公告）日：2006-01-12

  The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).