3-chloro-7-methoxy-thioxanthen-9-one | 86456-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: 3-chloro-7-methoxy-thioxanthen-9-one
• 英文别名: 3-chloro-7-methoxy-9H-thioxanthen-9-one；6-chloro-2-methoxy-9H-thioxanthen-9-one；3-chloro-7-methoxythioxanthen-9-one；6-chloro-2-methoxythioxanthen-9-one
• CAS: 86456-00-0
• 化学式: C₁₄H₉ClO₂S
• 分子量: 276.743
• InChiKey: JIXBMLPFMLMPBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-chloro-7-methoxy-thioxanthen-9-one 生成 1-<<2-(dimethylamino)ethyl>amino>-7-methoxy-9H-thioxanthen-9-one
  参考文献：
  名称：

  ARCHER, S.

  摘要：

  DOI：
• 作为产物：
  描述：

  间氯溴苯 在 PPA 、 铜 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 3-chloro-7-methoxy-thioxanthen-9-one
  参考文献：
  名称：

  Analogs of hycanthone and lucanthone as antitumor agents

  摘要：

  Hycanthone analogues (5 and 6) containing 7-substituted hydroxyl groups were prepared and evaluated as antitumor agents. These compounds were significantly more active than the corresponding unsubstituted derivatives. The 7-hydroxylated 4-(hydroxymethyl)-9H-xanthen-9-ones, 11 and 12, were also active antitumor agents. However, the 7-hydroxy-9H-xanthen-9-one counterparts of the 7-hydroxylucanthones were totally devoid of antitumor activity. Results obtained thus far are consistent with the hypothesis that 4-hydroxymethyl substituents in the 9H-xanthen-9-one and 9H-thioxanthen-9-one series are required for antitumor activity.

  DOI：

  10.1021/jm00363a007

文献信息

• Benzothiopyranoindazole antitumor agents
  申请人：Sterling Winthrop Inc.

  公开号：US05532263A1

  公开（公告）日：1996-07-02

  Novel 2H-[1]benzothiopyrano[4,3,2-cd]indazoles are disclosed as antitumor agents. Compositions containing the benzothiopyranoindazoles and methods of treating tumors and cancer in mammals with benzothiopyranoindazoles are also disclosed.

  揭示了作为抗肿瘤剂的新型2H-[1]苯并硫杂吡喃并[4,3,2-cd]吲哚酮。还揭示了含有苯并硫杂吡喃并吲哚酮的组合物以及使用苯并硫杂吡喃并吲哚酮治疗哺乳动物肿瘤和癌症的方法。
• [EN] LYOPHILIZED THIOXANTHENONE ANTIMUMOR AGENTS<br/>[FR] THIOXANTHENONE LYOPHILISEE COMME AGENTS ANTITUMORAUX
  申请人：SANOFI

  公开号：WO1997010809A1

  公开（公告）日：1997-03-27

  (EN) Disclosed are reconstituted lyophilized formulations for the treatment of mammalian tumors comprising a thioxanthenone antitumor agent in combination with mannitol or sucrose as a stabilizer in a lactate buffer.(FR) La présente invention concerne des formulations lyophilisées reconstituées destinées au traitement de tumeurs de mammifères. Ces formulations comprennent un agent antitumoral, à savoir la thioxanthénone, combinée à un stabilisant, en l'occurrence le mannitol ou le saccharose, dans un tampon de lactate.

  揭示了一种重组冻干配方，用于治疗哺乳动物肿瘤，包括一种硫代三环酮抗肿瘤剂与甘露醇或蔗糖作为稳定剂，在乳酸缓冲液中组合使用。
• Thioxanthenone antitumor agents
  申请人：Sanofi-Aventis

  公开号：EP1197491B1

  公开（公告）日：2004-12-29
• AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2842937B1

  公开（公告）日：2018-01-17
• ARCHER, S.
  作者：ARCHER, S.

  DOI：——

  日期：——