5-iodo-benzo[1,2,5]oxadiazole | 51294-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: 5-iodo-benzo[1,2,5]oxadiazole
• 英文别名: 5-Jodbenzofurazan；5-Iodobenzo[c][1,2,5]oxadiazole；5-iodo-2,1,3-benzoxadiazole
• CAS: 51294-40-7
• 化学式: C₆H₃IN₂O
• 分子量: 246.007
• InChiKey: JFMQEVNIDXHTSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  4-碘-1,2-二硝基-苯 在 sodium azide 作用下， 以 乙二醇 为溶剂， 生成 5-iodo-benzo[1,2,5]oxadiazole
  参考文献：
  名称：

  Di Nunno,L. et al., Journal of the Chemical Society. Perkin transactions I, 1973, p. 1954 - 1955

  摘要：

  DOI：

文献信息

• Compounds for nonsense suppression, and methods for their use
  申请人：PTC Therapeutics, Inc.

  公开号：EP2311455B1

  公开（公告）日：2015-07-15
• COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE
  申请人：PTC Therapeutics, Inc.

  公开号：US20170204073A1

  公开（公告）日：2017-07-20

  The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
• US9611230B2
  申请人：——

  公开号：US9611230B2

  公开（公告）日：2017-04-04
• [EN] METHOD OF BLOCKING TRANSMISSION OF MALARIAL PARASITE<br/>[FR] PROCÉDÉ DE BLOCAGE DE LA TRANSMISSION D'UN PARASITE PALUDÉEN
  申请人：US HEALTH

  公开号：WO2015073804A2

  公开（公告）日：2015-05-21

  The invention provides a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula I: wherein A, B, R1, R2, R10, and R11 are described herein, either alone or in combination with a second compound selected from elesclomol, NSC 174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1 152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
• Di Nunno,L. et al., Journal of the Chemical Society. Perkin transactions I, 1973, p. 1954 - 1955
  作者：Di Nunno,L. et al.

  DOI：——

  日期：——