1-[4-(1,1-diphenyl-methyl)-piperazin-1-yl]-1-[(S)-1-(4-fluoro-benzyl)-piperidin-2-yl]-methanone | 354563-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[4-(1,1-diphenyl-methyl)-piperazin-1-yl]-1-[(S)-1-(4-fluoro-benzyl)-piperidin-2-yl]-methanone
• 英文别名: (4-benzhydrylpiperazin-1-yl)-[(2S)-1-[(4-fluorophenyl)methyl]piperidin-2-yl]methanone
• CAS: 354563-68-1
• 化学式: C₃₀H₃₄FN₃O
• 分子量: 471.618
• InChiKey: QARLQTNTLKSIJH-NDEPHWFRSA-N

物化性质

• 沸点：
  594.3±50.0 °C(Predicted)
• 密度：
  1.184±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[4-(1,1-diphenyl-methyl)-piperazin-1-yl]-1-[(S)-1-(4-fluoro-benzyl)-piperidin-2-yl]-methanone 生成 1-((S)-1-Benzyl-piperidin-2-yl)-1-[4-(1,1-diphenyl-methyl)-piperazin-1-yl]-methanone
  参考文献：
  名称：

  Modulators of the cholesterol biosynthetic pathway

  摘要：

  本发明涉及调节胆固醇生物合成途径的方法。体内胆固醇水平与许多病理状态相关。本发明的方法改变了参与胆固醇生物合成的基因的转录水平。本发明的方法可用于治疗由胆固醇生物合成途径介导的疾病。

  公开号：

  US20030191110A1
• 作为产物：
  描述：

  1-[4-(1,1-Diphenyl-methyl)-piperazin-1-yl]-1-(S)-piperidin-2-yl-methanone dihydrochloride 在 potassium carbonate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 以42%的产率得到1-[4-(1,1-diphenyl-methyl)-piperazin-1-yl]-1-[(S)-1-(4-fluoro-benzyl)-piperidin-2-yl]-methanone
  参考文献：
  名称：

  Modulators of the cholesterol biosynthetic pathway

  摘要：

  本发明涉及调节胆固醇生物合成途径的方法。体内胆固醇水平与许多病理状态相关。本发明的方法改变了参与胆固醇生物合成的基因的转录水平。本发明的方法可用于治疗由胆固醇生物合成途径介导的疾病。

  公开号：

  US20030191110A1

文献信息

• Piperazine and piperidine derivatives
  申请人：——

  公开号：US20040034019A1

  公开（公告）日：2004-02-19

  The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.

  本发明涉及哌嗪和哌啶衍生物，特别适用于治疗或预防神经元损伤，特别是与神经系统疾病相关的损伤。这些化合物还可用于促进神经生长。本发明还提供了包括本发明化合物的组合物以及利用这些组合物治疗或预防神经元损伤或促进神经生长的方法。
• PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1257544B1

  公开（公告）日：2012-07-25
• MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1441728A2

  公开（公告）日：2004-08-04
• [EN] PIPERAZINE AND PIPERIDINE DERIVATIVES<br/>[FR] DERIVES DE PIPERAZINE ET DE PIPERIDINE
  申请人：VERTEX PHARMA

  公开号：WO2001058891A2

  公开（公告）日：2001-08-16

  The present invention relates to piperazine and piperidine derivatives of Formula (1), with Q, X, Y, A, B and P as defined herein, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.
• [EN] MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY<br/>[FR] MODULATEURS DE LA VOIE BIOSYNTHETIQUE DU CHOLESTEROL
  申请人：VERTEX PHARMA

  公开号：WO2003037338A2

  公开（公告）日：2003-05-08

  The present invention relates to methods for modulating the cholesterol biosynthetic pathway. The level of cholesterol in the body is linked to numerous pathological states. The methods fo the present invention alter the transcription levels of genes involved in the cholesterol biosynthesis. The methods of the present invention can used for treating diseases mediated by the cholesterol biosynthetic pathway.