1-((2R,3R,4S,5R)-5-((6-(tetradecylamino)pyrimidin-4-ylamino)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | 1271790-35-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: 1-((2R,3R,4S,5R)-5-((6-(tetradecylamino)pyrimidin-4-ylamino)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 英文别名: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[[6-(tetradecylamino)pyrimidin-4-yl]amino]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 1271790-35-2
• 化学式: C₂₈H₄₆N₆O₅
• 分子量: 546.71
• InChiKey: QEKOZCFFALEIKH-VBCUVWSKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  39
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  149
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1-((3aR,4R,6R,6aR)-2,2-dimethyl-6-((6-(tetradecylamino)pyrimidin-4-ylamino)methyl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 在 三氟乙酸 作用下， 以 水 为溶剂， 反应 0.33h， 以85%的产率得到1-((2R,3R,4S,5R)-5-((6-(tetradecylamino)pyrimidin-4-ylamino)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  Synthesis and antitumor activity of novel ribonucleosides with C-5 OH replaced by a diaminopyrimidinyl group

  摘要：

  A series of novel ribonucleosides with C-5 OH replaced by a diaminopyrimidinyl group were synthesized by successively nucleophilic substitutions of 5'-deoxy-5'-amino-ribonucleosides with 2,4-dichloropyrimidine and then with various fatty amines under microwave irradiation. Their anticancer activities in vitro were preliminarily evaluated. Compounds 7a and 8a only exhibited anticancer activity against A549 cell line with the IC50 values of 10.73 and 10.99 mu M, respectively. In addition, 7h and 8h showed potent activities against both A549 and Hela cell lines with the IC50 values of 12.71, 8.55 and 8.44, 5.55 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.069

文献信息

• Synthesis and antitumor activity of novel ribonucleosides with C-5 OH replaced by a diaminopyrimidinyl group
  作者：Kerang Wang、Ling Wu、Zhanbin Qin、Xinhao Yan、Xiaoliu Li、Hua Chen、Pingzhu Zhang、Jinchao Zhang

  DOI：10.1016/j.bmcl.2010.12.069

  日期：2011.2

  A series of novel ribonucleosides with C-5 OH replaced by a diaminopyrimidinyl group were synthesized by successively nucleophilic substitutions of 5'-deoxy-5'-amino-ribonucleosides with 2,4-dichloropyrimidine and then with various fatty amines under microwave irradiation. Their anticancer activities in vitro were preliminarily evaluated. Compounds 7a and 8a only exhibited anticancer activity against A549 cell line with the IC50 values of 10.73 and 10.99 mu M, respectively. In addition, 7h and 8h showed potent activities against both A549 and Hela cell lines with the IC50 values of 12.71, 8.55 and 8.44, 5.55 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.