2-甲基-3-(1-哌啶基)苯甲酸 | 886501-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2-甲基-3-(1-哌啶基)苯甲酸
• 英文名称: 2-Methyl-3-(1-piperidinyl)benzoic Acid
• 英文别名: 2-methyl-3-piperidin-1-ylbenzoic acid
• CAS: 886501-22-0
• 化学式: C₁₃H₁₇NO₂
• mdl: MFCD06740060
• 分子量: 219.28
• InChiKey: RZQWNANFHHDHHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  399.1±35.0 °C(Predicted)
• 密度：
  1.151±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel piperidine derivatives for use in the treatment of chemokine medicated disease states
  申请人：Luckhurst Christopher

  公开号：US20060040984A1

  公开（公告）日：2006-02-23

  The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.

  本发明提供了一个公式(I)的化合物：其中变量在此定义；以及制备这种化合物的过程；以及将这种化合物用于治疗趋化因子（例如CCR3）或H1介导的疾病状态的用途。
• Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US11203582B2

  公开（公告）日：2021-12-21

  Novel 3-(N-piperidinyl)methyl benzamide derivatives are disclosed. The compounds can be used in treating diseases and conditions which are associated with abnormal cell function related to endoplasmic reticulum (ER) stress. For example, the compounds can be used as suppressors of ER stress-induced pancreatic β-cell dysfunction and death, for example in the treatment of diabetes.

  新型3-(N-哌啶基)甲基苯甲酰胺衍生物被披露。这些化合物可用于治疗与内质网(ER)应激相关的异常细胞功能相关的疾病和病症。例如，这些化合物可作为ER应激诱导的胰腺β细胞功能障碍和死亡的抑制剂，例如在治疗糖尿病中使用。
• LSD1 INHIBITORS AND USES THEREOF
  申请人：Constellation Pharmaceuticals, Inc.

  公开号：US20180290976A1

  公开（公告）日：2018-10-11

  Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
• BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US20200199094A1

  公开（公告）日：2020-06-25

  Novel 3-(N-piperidinyl)methyl benzamide derivatives are disclosed. The compounds can be used in treating diseases and conditions which are associated with abnormal cell function related to endoplasmic reticulum (ER) stress. For example, the compounds can be used as suppressors of ER stress-induced pancreatic β-cell dysfunction and death, for example in the treatment of diabetes.
• METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY
  申请人：Children's Medical Center Corporation

  公开号：US20200255527A1

  公开（公告）日：2020-08-13

  Provided herein are methods of treating cancer using LSD1 inhibitors in combination with immunotherapy.