N-<2-(morpholin-4-yl)ethyl>glutarimide | 89003-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-<2-(morpholin-4-yl)ethyl>glutarimide
• 英文别名: 1-[2-(Morpholin-4-yl)ethyl]piperidine-2,6-dione；1-(2-morpholin-4-ylethyl)piperidine-2,6-dione
• CAS: 89003-42-9
• 化学式: C₁₁H₁₈N₂O₃
• 分子量: 226.276
• InChiKey: IZUSNPRVXUSFAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-<2-(morpholin-4-yl)ethyl>glutarimide 以 乙腈 为溶剂， 以77%的产率得到7-(morpholin-4-yl)perhydroazocine-2,5-dione
  参考文献：
  名称：

  Coyle, John D.; Bryant, Laurence, R. B., Journal of the Chemical Society. Perkin transactions I, 1983, # 12, p. 2857 - 2865

  摘要：

  DOI：

文献信息

• GLUTARIMIDE DERIVATIVES, USE THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS FOR PRODUCING GLUTARIMIDE DERIVATIVES
  申请人：Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"

  公开号：EP3722290A1

  公开（公告）日：2020-10-14

  The present invention relates to a novel biologically active glutarimide derivative of the following formula or a pharmaceutically acceptable salt thereof: Moreover, the present invention relates to the glutarimide derivative or the pharmaceutically acceptable salt thereof for use in the treatment of a respiratory tract disease, to a pharmaceutical composition for use in the treatment of a respiratory tract disease comprising an effective amount of the glutarimide derivative or the pharmaceutically acceptable salt thereof, and to a method for preparing the glutarimide derivative or the pharmaceutically acceptable salt thereof.

  本发明涉及下式的新型生物活性戊二酰亚胺衍生物或其药学上可接受的盐： 此外，本发明涉及用于治疗呼吸道疾病的戊二酰亚胺衍生物或其药学上可接受的盐，涉及用于治疗呼吸道疾病的药物组合物，其中包含有效量的戊二酰亚胺衍生物或其药学上可接受的盐，还涉及制备戊二酰亚胺衍生物或其药学上可接受的盐的方法。
• Glutarimide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing glutarimide derivatives
  申请人：OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “PHARMENTERPRISES”

  公开号：US10196377B2

  公开（公告）日：2019-02-05

  A compound having the following formula: or a pharmaceutically acceptable salt thereof. A medicament or pharmaceutical composition contains the compound. A method of treating a respiratory tract disease includes administering to a patient an effective amount of a compound or a pharmaceutically acceptable salt thereof.

  具有下式的化合物 或其药学上可接受的盐。药物或药物组合物含有该化合物。一种治疗呼吸道疾病的方法包括向患者施用有效量的化合物或其药学上可接受的盐。
• COYLE, J. D.;BRYANT, L. R. B., J. CHEM. SOC. PERKIN TRANS., 1983, N 12, 2857-2865
  作者：COYLE, J. D.、BRYANT, L. R. B.

  DOI：——

  日期：——
• Glutarimide Derivatives, Use Thereof, Pharmaceutical Composition Based Thereon and Methods for Producing Glutarimide Derivatives
  申请人：OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES"

  公开号：US20180016255A1

  公开（公告）日：2018-01-18

  A medicament or pharmaceutical composition for the treatment of exacerbations of asthma and chronic obstructive pulmonary disease, which is a compound having the following formula: or a pharmaceutically acceptable salt thereof. A method of treating exacerbations of asthma and chronic obstructive pulmonary disease includes administering to a patient an effective amount of the compound or a pharmaceutically acceptable salt thereof.
• US9815814B2
  申请人：——

  公开号：US9815814B2

  公开（公告）日：2017-11-14