3-[[(2R,3S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile | 201932-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3-[[(2R,3S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• CAS: 201932-40-3
• 化学式: C₄₀H₄₉N₄O₈P
• 分子量: 744.825
• InChiKey: QSKKBPLQRDWMSZ-QLXZDLSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  53
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  132
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1,4-脱水-2-脱氧-2-(胸腺激素-1-基)-D-阿拉伯糖醇 在 吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 生成 3-[[(2R,3S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
  参考文献：
  名称：

  Synthesis and Duplex Stabilization of Oligonucleotides Consisting of Isonucleosides

  摘要：

  Novel oligonucleotide analogues built from isonucleosides were synthesized by the phosphoramidite approach on an automated DNA synthesizer. The phosphoramidite building blocks were synthesized by phosphitylation of the corresponding protected isonucleosides. The oligonucleotide analogues C - G containing the isonucleoside 1-3 were studied with respect to their hybridization properties and enzymatic stability. The oligomers bearing an isonucleoside at the end of the strands all proved stable towards snake-venom phosphodiesterase, but only the oligomers D-G exhibit acceptable duplex stability when hybridized with complementary d(A(14)).

  DOI：

  10.1002/(sici)1522-2675(19991110)82:11<2037::aid-hlca2037>3.0.co;2-i

文献信息

• Novel oligodeoxyribonucleotides incorporating L-related isodeoxynucleosides: Solid phase synthesis, enzymology, and CD studies
  作者：Thomas Wenzel、Vasu Nair

  DOI：10.1016/s0960-894x(97)10183-4

  日期：1997.12

  The synthesis of self-complementary oligodeoxyribonucleotides incorporating the L-related isodeoxynucleosides, isodA, (1) and/or isodT (4) is described. These novel oligomers exhibit high resistance towards exonucleases, Temperature-and concentration-dependent CD spectra and thermodynamic data of the oligomers show that isodA-isodT base pairs participate in duplex stabilization. (C) 1997 Elsevier Science Ltd.
• Synthesis and Duplex Stabilization of Oligonucleotides Consisting of Isonucleosides
  作者：Zhenjun Yang、Huyi Zhang、Jimei Min、Lingtai Ma、Lihe Zhang

  DOI：10.1002/(sici)1522-2675(19991110)82:11<2037::aid-hlca2037>3.0.co;2-i

  日期：1999.11.10

  Novel oligonucleotide analogues built from isonucleosides were synthesized by the phosphoramidite approach on an automated DNA synthesizer. The phosphoramidite building blocks were synthesized by phosphitylation of the corresponding protected isonucleosides. The oligonucleotide analogues C - G containing the isonucleoside 1-3 were studied with respect to their hybridization properties and enzymatic stability. The oligomers bearing an isonucleoside at the end of the strands all proved stable towards snake-venom phosphodiesterase, but only the oligomers D-G exhibit acceptable duplex stability when hybridized with complementary d(A(14)).