potassium butylthiolate | 26385-25-1

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: potassium butylthiolate
• 英文别名: butane-1-thiol; potassium salt；potassium butanethiolate；potassium;butane-1-thiolate
• CAS: 26385-25-1
• 化学式: C₄H₉S*K
• 分子量: 128.28
• InChiKey: YYEDFKLAAIDHNE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.66
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-氯-2-甲基-3-吗啉丙烷 、 potassium butylthiolate 生成 4-(3-butylsulfanyl-2-methyl-propyl)-morpholine
  参考文献：
  名称：

  Profft,E.; Oberender,H., Journal fur praktische Chemie (Leipzig 1954), 1964, vol. 25, p. 225 - 271

  摘要：

  DOI：
• 作为产物：
  描述：

  丁硫醇 、 potassium tert-butylate 生成 potassium butylthiolate
  参考文献：
  名称：

  RUSSELL, G. A.;ROS, F., J. AMER. CHEM. SOC., 1985, 107, N 8, 2506-2511

  摘要：

  DOI：
• 作为试剂：
  描述：

  丁硫醇 、 乙炔 在 18-冠醚-6 potassium butylthiolate 作用下， 以 甲苯 为溶剂， 生成 连翘脂苷B
  参考文献：
  名称：

  An Effecient and Safe Method for the Preparation of Alkyl Vinyl Sulfides

  摘要：

  DOI：

  10.1002/prac.19963380133

文献信息

• Cyclodextrin liquid crystals: synthesis and self-organisation of amphiphilic thio-β-cyclodextrins
  作者：Chang-Chun Ling、Raphael Darcy、Wilhelm Risse

  DOI：10.1039/c39930000438

  日期：——

  Heptakis(6-S-alkyl-6-thio)-cyclomaltoheptaoses (where alkyl is a C2, C4, C10, C16 and C18 unit) have been synthesised via heptakis(6-bromo-6-deoxy)-cyclomaltoheptaose and shown to form thermotropic liquid crystals.

  Heptakis（6-小号-烷基-6-硫代）-cyclomaltoheptaoses（其中烷基是C 2，C 4，C 10，C 16和C 18单元）已合成经由heptakis（6-溴-6-脱氧） -并显示形成热致液晶。
• New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 1. Synthesis and microbiological evaluation
  作者：A. Van Schepdael、J. Delcourt、M. Mulier、R. Busson、L. Verbist、H. J. Vanderhaeghe、M. P. Mingeot-Leclercq、P. M. Tulkens、P. J. Claes

  DOI：10.1021/jm00108a035

  日期：1991.4

  The clinical use of the potent, wide-spectrum aminoglycoside antibiotics is limited by oto- and nephrotoxicities. The latter is related to the binding of these polycationic drugs to negatively charged phospholipids and to the subsequent inhibition of lysosomal phospholipases. In order to explore the influence of a modification of the hydrophobic/hydrophilic balance at a specific site of an aminoglycoside, kanamycin B has been chemically modified in position 6" by substitution of the hydroxyl group with a halogen atom (or a pseudohalogen group), or an amino, an amido, a thioalkyl, or an alkoxy group, each series containing increasingly bulkier chains. Examination of the antibacterial activity of the synthesized compounds revealed a negative correlation between the size of the 6"-substituent and the antibacterial activity against kanamycin B sensitive Gram-positive and -negative organisms. Only derivatives with small substituents in position 6", namely chloro, bromo, azido, amino, methylcarbamido, acetamido, methylthio, methylsulfinyl, O-methyl, O-ethyl, and O-isopropyl, showed acceptable activity (geometric mean of minimum inhibitory concentrations for Gram-negative strains less-than-or-equal-to 2.5 mg/L; value for kanamycin B, 0.5 mg/L). In vitro toxicological evaluation of all derivatives and computer-aided conformational analysis of selected compounds inserted in a phosphatidylinositol monolayer are presented in the following paper in this issue.
• Kalashnikov,V.P.; Zemlyanskii,N.I., Journal of general chemistry of the USSR, 1969, vol. 39, # 3, p. 570 - 573
  作者：Kalashnikov,V.P.、Zemlyanskii,N.I.

  DOI：——

  日期：——
• Peeran, S. G.; Venkateswarlu, R.; Reddy, G. Hanumantha, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 223 - 227
  作者：Peeran, S. G.、Venkateswarlu, R.、Reddy, G. Hanumantha

  DOI：——

  日期：——
• Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties
  作者：Ho Sik Rho、Soo Mi Ahn、Dae Sung Yoo、Myung Kyoo Kim、Dong Ha Cho、Jae Youl Cho

  DOI：10.1016/j.bmcl.2010.09.042

  日期：2010.11

  This study was conducted to examine the tyrosinase inhibitory and anti-inflammatory activities of kojic acid derivatives. A series of kojic acid derivatives containing thioether, sulfoxide, and sulfone linkages were synthesized. In the tyrosinase assay, kojyl thioether derivatives containing appropriate lipophilic alkyl chains (pentane, hexane, and cyclohexane) showed potent inhibitory activity. However, sulfoxides and sulfones exhibited decreased activity. Similar experimental results were obtained with inhibitory activities of NO production being induced by LPS. The presence of thioether linkage and appropriated lipophilic acid moiety was critical for the tyrosinase inhibitory and anti-inflammatory activities. (C) 2010 Elsevier Ltd. All rights reserved.