4-methoxy-6-morpholino-[1,3,5]triazin-2-ylamine | 141606-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-methoxy-6-morpholino-[1,3,5]triazin-2-ylamine
• 英文别名: 4-Methoxy-6-morpholino-[1,3,5]triazin-2-ylamin；4-Methoxy-6-(morpholin-4-yl)-1,3,5-triazin-2-amine；4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-amine
• CAS: 141606-78-2
• 化学式: C₈H₁₃N₅O₂
• mdl: MFCD00447580
• 分子量: 211.224
• InChiKey: TVRAAVMUXMRIAE-UHFFFAOYSA-N

物化性质

• 沸点：
  445.4±55.0 °C(Predicted)
• 密度：
  1.330±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,5-二甲氧基四氢呋喃 、 4-methoxy-6-morpholino-[1,3,5]triazin-2-ylamine 在 phosphorus pentoxide 作用下， 以 甲苯 为溶剂， 以85%的产率得到2-methoxy-4-morpholin-4-yl-6-(1H-pyrrol-1-yl)-1,3,5-triazine
  参考文献：
  名称：

  三嗪类。8. 4,6-二取代的2-（1H-吡咯基）-1,3,5-三嗪的合成及一些反应

  摘要：

  We have studied the reaction of 2,5-dimethoxytetrahydrofuran with 4,6-disubstituted 2-amino-1,3,5-triazines with the aim of obtaining novel coupled polyheterocyclic systems with potential bioactivity. Reaction conditions were optimized. A series of novel 4,6-disubstituted 2-(1H-1-pyrrolyl)-sym-triazines was obtained. It was found that the product yields depended on the nature of the substituent in the 4 and 6 positions of the triazine ring and on the reaction conditions.

  DOI：

  10.1007/s10593-008-0050-4
• 作为产物：
  描述：

  4-chloro-6-morpholino-1,3,5-triazin-2-amine 、 sodium methylate 在 甲醇 作用下， 生成 4-methoxy-6-morpholino-[1,3,5]triazin-2-ylamine
  参考文献：
  名称：

  Alkoxy-s-triazines. II

  摘要：

  DOI：

  10.1021/ja01171a521

文献信息

• sym-triazines. 8. Synthesis and some reactions of 4,6-disubstituted 2-(1H-pyrrolyl)-1,3,5-triazines
  作者：A. A. Chesnyuk、S. N. Mikhailichenko、V. N. Zaplishnyi、L. D. Konyushkin、S. I. Firgang

  DOI：10.1007/s10593-008-0050-4

  日期：2008.3

  We have studied the reaction of 2,5-dimethoxytetrahydrofuran with 4,6-disubstituted 2-amino-1,3,5-triazines with the aim of obtaining novel coupled polyheterocyclic systems with potential bioactivity. Reaction conditions were optimized. A series of novel 4,6-disubstituted 2-(1H-1-pyrrolyl)-sym-triazines was obtained. It was found that the product yields depended on the nature of the substituent in the 4 and 6 positions of the triazine ring and on the reaction conditions.
• Alkoxy-<i>s</i>-triazines. II
  作者：William M. Pearlman、C. K. Banks

  DOI：10.1021/ja01171a521

  日期：1949.3