Tert-butyl 2-methoxy-6-methylpiperidine-1-carboxylate | 1024684-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Tert-butyl 2-methoxy-6-methylpiperidine-1-carboxylate
• 英文别名: tert-butyl 2-methoxy-6-methylpiperidine-1-carboxylate
• CAS: 1024684-36-3
• 化学式: C₁₂H₂₃NO₃
• 分子量: 229.32
• InChiKey: RNYLDFLSNHAVMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 2-methoxy-6-methylpiperidine-1-carboxylate 在 silica gel 作用下， 生成 1,2,3,4-tetrahydro-2-methylpyridine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

  摘要：

  N-Protecting groups of alpha-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into alpha'-methoxylated compounds, while N-cyano derivatives changed into alpha-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the alpha-methoxylated compounds protected with cyano group afforded alpha,alpha-disubstituted cyclic amines. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.060
• 作为产物：
  描述：

  甲醇 、 tert-butyl 2-methylpiperidine-1-carboxylate 在 N,N,N,N-tetraethylammonium tetrafluoroborate 作用下， 生成 Tert-butyl 2-methoxy-6-methylpiperidine-1-carboxylate
  参考文献：
  名称：

  High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

  摘要：

  N-Protecting groups of alpha-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into alpha'-methoxylated compounds, while N-cyano derivatives changed into alpha-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the alpha-methoxylated compounds protected with cyano group afforded alpha,alpha-disubstituted cyclic amines. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.060

文献信息

• High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines
  作者：Samuel S. Libendi、Yosuke Demizu、Yoshihiro Matsumura、Osamu Onomura

  DOI：10.1016/j.tet.2008.02.060

  日期：2008.4

  N-Protecting groups of alpha-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into alpha'-methoxylated compounds, while N-cyano derivatives changed into alpha-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the alpha-methoxylated compounds protected with cyano group afforded alpha,alpha-disubstituted cyclic amines. (c) 2008 Elsevier Ltd. All rights reserved.