2-苄基-1,3,5-三嗪 | 30361-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 2-苄基-1,3,5-三嗪
• 英文名称: 2-benzyl-[1,3,5]triazine
• 英文别名: benzyl-[1,3,5]triazine；Benzyl-[1,3,5]triazin；2-Benzyl-1,3,5-triazin；2-Benzyl-s-triazin；2-Benzyl-1,3,5-triazine
• CAS: 30361-89-8
• 化学式: C₁₀H₉N₃
• 分子量: 171.202
• InChiKey: PNCKWHDODAETSN-UHFFFAOYSA-N

物化性质

• 沸点：
  100-105 °C(Press: 2 Torr)
• 密度：
  1.152±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3,5-三嗪 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙腈 作用下， 生成 2-苄基-1,3,5-三嗪 、 2,4-dibenzyl-[1,3,5]triazine
  参考文献：
  名称：

  Synthesis of the sym-Triazine System. II.¹ Preparation of Monosubstituted sym-Triazines by Reaction of sym-Triazine with Amidines

  摘要：

  DOI：

  10.1021/ja01515a047

文献信息

• AROMATIC RING FUSED TRIAZINE DERIVATIVES AND USES THEREOF
  申请人：Zhao Linxiang

  公开号：US20110183972A1

  公开（公告）日：2011-07-28

  The invention belongs to pharmaceutical field. The invention relates to the compounds according to Formula I, including their optically active forms, pharmaceutically acceptable salts or hydrates, and the pharmaceutical composition comprising thereof as active ingredient; uses in the preparation of vascular endothelial growth factor receptor tyrosine kinase inhibitors, and uses in the preparation of medicament for the treatment and/or prevention of cancer.

  本发明属于药物领域。本发明涉及根据公式I的化合物，包括它们的光学活性形式、药物可接受的盐或水合物，以及包含它们作为活性成分的药物组合物；用于制备血管内皮生长因子受体酪氨酸激酶抑制剂的使用，以及用于制备治疗和/或预防癌症的药物的使用。
• POLYMERIC REAGENTS COMPRISING A TERMINAL VINYLIC GROUP AND CONJUGATES FORMED THEREFROM
  申请人：Culbertson Sean M.

  公开号：US20120318701A1

  公开（公告）日：2012-12-20

  The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

  本发明提供了具有可降解连接的共轭物和用于制备这种共轭物的高分子试剂。还提供了制备高分子试剂和共轭物的方法，以及给予共轭物和组合物的方法。
• METHODS FOR PREPARING POLYMERIC REAGENTS
  申请人：Nektar Therapeutics

  公开号：US20150141665A1

  公开（公告）日：2015-05-21

  The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.

  本发明提供了制备聚合试剂的方法，其中该方法包括（a）提供一种带有羟基、第一氨基和第二氨基的芳香基团；（b）将功能性试剂与羟基反应，以得到带有功能性基团的羟基，该功能性基团能够与活性剂的氨基反应，并产生可水解的碳酸酯；以及（c）将带有反应性基团的多种聚（烷基乙二醇）水溶性聚合物与第一氨基和第二氨基反应，以得到（i）通过间隔基团带有第一氨基的水溶性聚合物，以及（ii）通过间隔基团带有第二氨基的第二种水溶性聚合物。
• Methods for Preparing Conjugates
  申请人：Nektar Therapeutics

  公开号：US20130184443A1

  公开（公告）日：2013-07-18

  The present invention provides pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a conjugate having a degradable linkage. The conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods for delivering such compositions are also provided.

  本发明提供了包含可降解连接的共轭物的药物组成物，其中包括药用可接受的辅料和共轭物。这些共轭物包括以下至少一种：含有可离解氢原子的芳香基团、间隔基团和水溶性聚合物。还提供了传递这种组成物的方法。
• Methods for Preparing Polymeric Reagents
  申请人：Nektar Therapeutics

  公开号：US20140107349A1

  公开（公告）日：2014-04-17

  The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.

  本发明提供了制备聚合试剂的方法，其中该方法包括(a)提供一种带有羟基、第一氨基和第二氨基的芳香基团；(b)将功能性试剂与羟基反应，得到带有能够与活性试剂的氨基基团反应并生成可水解的氨基甲酸酯的官能基的羟基基团；(c)将带有反应基团的多种聚(烷氧基乙烯醇)水溶性聚合物与第一氨基和第二氨基反应，得到(i)通过间隔基团带有第一氨基的水溶性聚合物，以及(ii)通过间隔基团带有第二氨基的第二种水溶性聚合物。