6-methyl-4-N-[(4-methylphenyl)methyl]-2-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazine-2,4-diamine | 1232144-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-methyl-4-N-[(4-methylphenyl)methyl]-2-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazine-2,4-diamine
• CAS: 1232144-69-2
• 化学式: C₂₁H₂₅N₅O₃
• 分子量: 395.461
• InChiKey: LHVTXDSLOYRJID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.4
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-amino-4-(3',4',5'-trimethoxyphenyl)amino-6-methyl-1,3,5-triazine 、 4-甲基苄溴 在 sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.25h， 以81%的产率得到6-methyl-4-N-[(4-methylphenyl)methyl]-2-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazine-2,4-diamine
  参考文献：
  名称：

  High yielding microwave-assisted synthesis of 2-(arylmethyl)amino-4-arylamino-6-alkyl-1,3,5-triazines

  摘要：

  An efficient and practical procedure was developed to prepare novel 2-(arylmethyl)amino-4-arylamino-6-alkyl-1,3,5-triazines, starting from dicyandiamide and the corresponding arylamines under microwave irradiation and its scope is demonstrated with a number of examples. The valuable feature of this procedure included the short reaction times, high yields, and easy operation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.042

文献信息

• High yielding microwave-assisted synthesis of 2-(arylmethyl)amino-4-arylamino-6-alkyl-1,3,5-triazines
  作者：Huixiong Chen、Pascal Dao、Alice Laporte、Christiane Garbay

  DOI：10.1016/j.tetlet.2010.04.042

  日期：2010.6

  An efficient and practical procedure was developed to prepare novel 2-(arylmethyl)amino-4-arylamino-6-alkyl-1,3,5-triazines, starting from dicyandiamide and the corresponding arylamines under microwave irradiation and its scope is demonstrated with a number of examples. The valuable feature of this procedure included the short reaction times, high yields, and easy operation. (C) 2010 Elsevier Ltd. All rights reserved.