N-succinimidyl-4--hydroxymethyl-benzoate | 132454-40-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-succinimidyl-4--hydroxymethyl-benzoate
• 英文别名: N-succinimidyl-4-[bis(4-methoxyphenyl)-hydroxymethyl]benzoate；N-Succinimidyl-4-[bis-(4methoxyphenyl)hydroxymethyl]benzoate；(2,5-Dioxopyrrolidin-1-yl) 4-[hydroxy-bis(4-methoxyphenyl)methyl]benzoate
• CAS: 132454-40-1
• 化学式: C₂₆H₂₃NO₇
• 分子量: 461.471
• InChiKey: VHVCLJKIFQVSCF-UHFFFAOYSA-N

物化性质

• 沸点：
  647.4±65.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-succinimidyl-4--hydroxymethyl-benzoate 在 乙酰氯 作用下， 生成 N-Succinimidyl-4--benzoate
  参考文献：
  名称：

  异双功能三苯甲基衍生物作为连接试剂，可在标记和固定后回收核酸

  摘要：

  描述了在对位5a或间位5b上带有N-羟基琥珀酸基团作为活性酯的两种杂双功能4,4'-二甲氧基三苯甲基衍生物的合成。虽然先前已经通过6个步骤合成了5a，但是本文介绍了这两种化合物的新颖且更有效的4个步骤。所述元化合物5b中提供了更酸不稳定tntyl相比醚键对位衍生物5a中。使用这些化合物作为连接剂，特别是核酸中的生物聚合物可以在标记或固定后通过用弱酸如80％乙酸水溶液处理而容易地回收。

  DOI：

  10.1016/0040-4020(95)00137-w
• 作为产物：
  描述：

  2-(4-溴苯基)-4,4-二甲基-4,5-二氢噁唑 在 sodium hydroxide 、 magnesium 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 反应 14.0h， 生成 N-succinimidyl-4--hydroxymethyl-benzoate
  参考文献：
  名称：

  A versatile acid-labile linker for modification of synthetic biomolecules

  摘要：

  DOI：

  10.1016/s0040-4039(00)97249-6

文献信息

• Succinimidyl trityl compounds and a process for preparing same
  申请人：PerSeptive Biosystems, Inc.

  公开号：US05410068A1

  公开（公告）日：1995-04-25

  The invention pertains to compounds and methods for the reversible modification of natural products, biopolymers or synthons for natural products or biopolymers, such as nucleosides, nucleotides, and oligonucleosides. The modification enables one to perform a variety of chemistries on these compounds, yet can be removed to regenerate functional groups on the natural products, biopolymer or synthon of interest.

  本发明涉及化合物和方法，用于可逆地修饰天然产物、生物聚合物或天然产物或生物聚合物的合成物，例如核苷、核苷酸和寡核苷酸。该修饰使得可以在这些化合物上执行各种化学反应，但可以去除以再生有用的功能基团，用于所需的天然产物、生物聚合物或合成物。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Reversible modification of biological compounds for detection, separation and purification thereof
  申请人：MILLIPORE CORPORATION

  公开号：EP0424819A1

  公开（公告）日：1991-05-02

  The invention pertains to compounds and methods for the reversible modification of natural products, biopolymers or synthons for natural products or bio­polymers, such as nucleosides, nucleotides, and oligo­nucleosides. The modification enables one to perform a variety of chemistries on these compounds, yet can be removed to regenerate functional groups on the natural products, biopolymer or synthon of interest.

  本发明涉及对天然产物、生物聚合物或天然产物或生物聚合物的合成物（如核苷、核苷酸和寡核苷酸）进行可逆修饰的化合物和方法。这种修饰使人们能够对这些化合物进行各种化学处理，同时还可以去除这些化合物，以在相关天然产物、生物聚合物或合成物上重新生成官能团。
• METHODS FOR IDENTIFYING DRUG NON-TARGET PROTEINS
  申请人：caprotec bioanalytics GmbH

  公开号：EP1583972B1

  公开（公告）日：2010-11-24
• Devices, systems and methods for separating magnetic particles
  申请人：Lenz Thomas

  公开号：US20100200405A1

  公开（公告）日：2010-08-12

  A method and device for separating from samples magnetic particles that contain capture compounds on their surfaces. The device includes a sheath including a magnet and including orienting pin adapted to concentrate or direct a magnetic field of the magnet; and a magnetizable plate with lid holes for receiving a vessel lid of a vessel, the magnetizable plate configured to receive the sheath and position the orienting pin over the vessel lid. In one method, magnetic beads with attached molecules are collected in the lids of the reaction vessel by the magnetic separator device provided herein and the separated magnetic particles, which carry the molecules of interest through affinity-based attachment chemistry and are held in the lid by the magnet of the device, are released into a new vessel containing a solution by removal of the separator device without the need for pipettes or liquid handling devices.