1,2,3,4-tetrahydrobenzanthracene-7,12-dione | 72648-43-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 角环素
• 英文名称: 1,2,3,4-tetrahydrobenzanthracene-7,12-dione
• 英文别名: 1,2,3,4-tetrahydrobenzanthraquinone；1,2,3,4-tetrahydro-benz[a]anthracene-7,12-dione；1,2,3,4-Tetrahydro-benz[a]anthracen-7,12-dion；1.2-Tetramethylen-anthrachinon；1,2,3,4-Tetrahydrobenzo[a]anthracene-7,12-dione
• CAS: 72648-43-2
• 化学式: C₁₈H₁₄O₂
• 分子量: 262.308
• InChiKey: AZESNEXPGASJRZ-UHFFFAOYSA-N

物化性质

• 熔点：
  135 °C
• 沸点：
  480.6±45.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

SDS

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tetrahydrobenzanthracene-7,12-dione 在 硫酸 、 肼 作用下， 以 乙二醇 为溶剂， 反应 5.0h， 以85%的产率得到1,2,3,4-tetrahydrobenzanthracen-12(7H)-one
  参考文献：
  名称：

  Synthesis of the angular ring tetrahydroepoxides of the carcinogens 7- and 12-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene

  摘要：

  DOI：

  10.1021/jo00265a025
• 作为产物：
  描述：

  2-(5,6,7,8-tetrahydro-1-naphtoyl)benzoic acid 在 硫酸 、 硼酸 作用下， 生成 1,2,3,4-tetrahydrobenzanthracene-7,12-dione
  参考文献：
  名称：

  Michailow; Tschernowa, Zhurnal Obshchei Khimii, 1942, vol. 12, p. 288,293

  摘要：

  DOI：

文献信息

• Synthesis and mutagenicity of A-ring reduced analogs of 7,12-dimethylbenz[a]anthracene
  作者：Muthiah N. Inbasekaran、Donald T. Witiak、Karen Barone、John C. Loper

  DOI：10.1021/jm00177a013

  日期：1980.3

  The synthesis and mutagenicity of two derivatives of 7,12-dimethylbenz[a]anthracene (DMBA; 1), i.e., 1,2-H2DMBA (4) and 1,2,3,4-H4DMBA (5), are reported. These analogues (4 and 5) represent dihydro and tetrahydro A-ring reduced forms of DMBA, a region in the parent hydrocarbon (1) proposed to be involved in metabolism to the ultimate carcinogen. The synthesis for 4 without isolation of intermediates

  报道了7,12-二甲基苯并[a]蒽（DMBA; 1）的两种衍生物，即1,2-H2DMBA（4）和1,2,3,4-H4DMBA（5）的合成和致突变性。这些类似物（4和5）代表DMBA的二氢和四氢A环还原形式，DMBA是母体烃（1）中提议参与最终致癌物代谢的区域。通过与8摩尔当量的CH3Li，HI和NaBH4连续反应，合成4，而无需从1,2,3,4-四氢苯并[a]蒽-4,7,12-三酮（10）的甲苯磺酰isolation中分离中间体代表了这种烃的新颖方法，目前已有足够数量的生物研究用。有趣的是，在存在或不存在针对菌株TA98和TA100的微粒体激活的情况下，这些还原的类似物4和5在Ames测定中均表现出诱变活性。在这些菌株中 DMBA仅在存在S-9馏分时才有活性。在缺乏质粒的菌株TA1537中，在不存在和存在S-9级分的情况下，仅四氢类似物5显示出诱变活性。
• PHOTOACID-GENERATING COMPOUND AND ASSOCIATED POLYMER, PHOTORESIST COMPOSITION, AND METHOD OF FORMING A PHOTORESIST RELIEF IMAGE
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US20180095363A1

  公开（公告）日：2018-04-05

  A photoacid-generating compound has the structure wherein m, n, R 1 , R 2 , X, Y, and Z − are defined herein. The photoacid-generating compound exhibits strong absorption and chemical sensitivity to extreme ultraviolet radiation, while also absorbing longer wavelengths with desirably reduced chemical sensitivity. Also described are a polymer incorporating the residue of a polymerizable version of the photoacid-generating compound, a photoresist composition that includes the photoacid-generating compound, the polymer, or a combination thereof, and a method of forming a photoresist relief image using the photoresist composition.

  一种光酸生成化合物具有结构，其中m、n、R1、R2、X、Y和Z−在此处定义。该光酸生成化合物对极紫外辐射具有强吸收和化学敏感性，同时还吸收较长波长并具有较低的化学敏感性。还描述了一种聚合物，其中包含可聚合版本的光酸生成化合物的残留物，一种包含该光酸生成化合物、聚合物或两者组合的光阻剂组合物，以及使用该光阻剂组合物形成光阻剂
• Two-photon absorption dye-containing material, three-dimensional refractive index modulation material, three-dimensional absorption index modulation material and three-dimensional optical recording material
  申请人：Takizawa Hiroo

  公开号：US20050019711A1

  公开（公告）日：2005-01-27

  To provide a two-photon absorption dye-containing material having a great off-resonant two-photon absorption cross section and comprising a two-photon absorption dye capable of decoloring itself through off-resonant two-photon absorption, useful for a three-dimensional refractive index or absorption index modulation material, a three-dimensional optical recording medium, three-dimensional refractive index modulation method and recording and reproducing method for a three-dimensional optical recording medium a two-photon absorption dye-containing material comprising at least a two-photon absorption dye capable of decoloring itself through two-photon absorption.

  提供一种具有较大离共振双光子吸收截面的含有双光子吸收染料的材料，包括能够通过离共振双光子吸收脱色的双光子吸收染料，适用于三维折射率或吸收率调制材料，三维光学记录介质，三维折射率调制方法以及三维光学记录介质的记录和再现方法，其中包括至少一种能够通过双光子吸收脱色的双光子吸收染料的双光子吸收染料含材料。
• PHOTOACID-GENERATING COMPOUND, POLYMER DERIVED THEREFROM, PHOTORESIST COMPOSITION INCLUDING THE PHOTOACID-GENERATING COMPOUND OR POLYMER, AND METHOD OF FORMING A PHOTORESIST RELIEF IMAGE
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US20180059542A1

  公开（公告）日：2018-03-01

  A photoacid-generating compound has the structure where R 1 , R 2 , R 3 , R 4 , Q, and X are defined herein. The photoacid-generating compound can be used as a component of a photoresist composition, or as a monomer incorporated into a polymer useful in a photoresist composition. The photoacid-generating compound provides a desired balance of solubility and line width roughness.

  一种具有以下结构的光酸发生化合物，其中R1、R2、R3、R4、Q和X在此定义。该光酸发生化合物可以用作光阻组分，或作为单体并入到聚合物中，用于光阻组分。该光酸发生化合物提供所需的溶解度和线宽粗糙度的平衡。
• N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION
  申请人：Aktas Bertal Huseyin

  公开号：US20120115915A1

  公开（公告）日：2012-05-10

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

  本文提供了抑制翻译起始的组合物和方法。描述了使用N，N'-二芳基脲和/或N，N'-二芳基硫脲化合物治疗（1）细胞增生性疾病，（2）非增生性退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。