N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl][1,3]oxazolo[5,4-c]pyridine-6-carboxamide | 478169-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶唑并吡啶类
• 英文名称: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl][1,3]oxazolo[5,4-c]pyridine-6-carboxamide
• 英文别名: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-[1,3]oxazolo[5,4-c]pyridine-6-carboxamide
• CAS: 478169-51-6
• 化学式: C₁₄H₁₆N₄O₂
• 分子量: 272.307
• InChiKey: IYKQEGPAWNKXQE-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Quinuclidine-substituted hetero-bicyclic aromatic compounds for the treatment of disease
  申请人：——

  公开号：US20030073707A1

  公开（公告）日：2003-04-17

  The invention provides compounds of Formula I: 1 wherein W 0 is a bicyclic moiety and is 2 These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful to treat diseases or conditions in which &agr;7 is known to be involved.

  这项发明提供了Formula I的化合物： 其中W0是一个双环基团，是 这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或混合物，对治疗已知涉及α7的疾病或症状有用。
• QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1404674A2

  公开（公告）日：2004-04-07
• US6828330B2
  申请人：——

  公开号：US6828330B2

  公开（公告）日：2004-12-07
• [EN] QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTIC ACETYLCHOLINE RECEPTORS<br/>[FR] COMPOSES AROMATIQUES HETERO-BICYCLIQUES SUBSTITUES PAR QUINUCLIDINE DANS LE TRAITEMENT DE MALADIES
  申请人：UPJOHN CO

  公开号：WO2002100858A2

  公开（公告）日：2002-12-19

  The invention provides compounds of Formula (I): wherein W0 is a bicyclic moiety and is (I). These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful to treat diseases or conditions in which α7 is known to be involved.