7,10-dimethoxy-3-methyl-1-propyl-1H-benzo[g]isochromene-6,9-dione | 915374-94-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异色满醌
• 英文名称: 7,10-dimethoxy-3-methyl-1-propyl-1H-benzo[g]isochromene-6,9-dione
• CAS: 915374-94-6
• 化学式: C₁₉H₂₀O₅
• 分子量: 328.365
• InChiKey: HJRTWBGNHFTSPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7,10-dimethoxy-3-methyl-1-propyl-1H-benzo[g]isochromene-6,9-dione 在 N-氯代丁二酰亚胺 作用下， 生成
  参考文献：
  名称：

  Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria

  摘要：

  Chloroquinocin 1 is an antimicrobial agent against Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). A successful synthesis of 1 was attained through a unique chlorination of the corresponding naphthoquinone derivative 12 as a key step. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.01.020
• 作为产物：
  描述：

  5-benzyloxy-3-bromo-4,7,8-trimethoxynaphthalene-2-carbaldehyde 在 正丁基锂 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成 7,10-dimethoxy-3-methyl-1-propyl-1H-benzo[g]isochromene-6,9-dione
  参考文献：
  名称：

  Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria

  摘要：

  Chloroquinocin 1 is an antimicrobial agent against Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). A successful synthesis of 1 was attained through a unique chlorination of the corresponding naphthoquinone derivative 12 as a key step. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.01.020

文献信息

• Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria
  作者：Akiko Shimbashi、Shigeru Nishiyama

  DOI：10.1016/j.tetlet.2007.01.020

  日期：2007.2

  Chloroquinocin 1 is an antimicrobial agent against Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). A successful synthesis of 1 was attained through a unique chlorination of the corresponding naphthoquinone derivative 12 as a key step. (c) 2007 Elsevier Ltd. All rights reserved.