1-benzyl-4(diphenylmethyl)piperidine | 86727-25-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-benzyl-4(diphenylmethyl)piperidine
• 英文别名: 4-Benzhydryl-1-benzylpiperidine
• CAS: 86727-25-5
• 化学式: C₂₅H₂₇N
• 分子量: 341.496
• InChiKey: XKZSBAUAGFJYTI-UHFFFAOYSA-N

物化性质

• 沸点：
  459.4±14.0 °C(Predicted)
• 密度：
  1.074±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol 在 磷化氢 、 氢碘酸 作用下， 反应 7.5h， 以4 g的产率得到1-benzyl-4(diphenylmethyl)piperidine
  参考文献：
  名称：

  Benzylpiperazine Derivatives. VII. Studies on the Role of the Nitrogen Atom in the Cerebral Vasodilating Activity of 1-Benzyl-4-diphenylmethylpiperazine Derivatives

  摘要：

  制备1-苄基-4-二苯基甲基哌啶衍生物以研究氮原子在其脑血管舒张活性中的作用。药理学测试结果表明，哌啶衍生物与我们的测试系统中的哌嗪衍生物大致等效。提出了结构-活性分析。

  DOI：

  10.1248/cpb.35.4637

文献信息

• Synthesis and structure-activity relationship of spiro(isochroman-piperidine) analogs for inhibition of histamine release. III.
  作者：MASATOSHI YAMATO、KUNIKO HASHIGAKI、KIWAMU HIRAMATSU、KENJI TASAKA

  DOI：10.1248/cpb.31.521

  日期：——

  Several 1-alkyl-4-piperidylidene analogs were synthesized and tested for inhibitory activity on the compound 48/80-induced release of histamine from mast cells. 4-(4-Isochromanylidene) (12b) and 4-(diphenylmethylene) (14) derivatives of 1-benzylpiperidine were much more active than the lead compounds, 1-benzylspiro [isochroman-piperidines] (1b and 2b).

  合成了几种 1-烷基-4-亚哌啶类似物，并测试了其对化合物 48/80 诱导的肥大细胞释放组胺的抑制活性。 1-苄基哌啶的 4-(4-异色满亚甲基) (12b) 和 4-(二苯基亚甲基) (14) 衍生物比先导化合物 1-苄基螺[异色满-哌啶] (1b 和 2b) 活性高得多。
• Substituted N-benzyl-4(benzhydryl) piperidines
  申请人：G.D. Searle & Co.

  公开号：EP0204309A2

  公开（公告）日：1986-12-10

  The invention relates to compounds of the formula: and the pharmaceutically acceptable salts thereof wherein Ar are the same or different and represent phenyl or halogen substituted phenyl; R is selected from lower alkoxy, or di (lower alkyl) amino; R1 is selected from hydrogen, lower alkoxy-carbonyl, carboxy, or lower alkylaminocarbonyl; and n is 0 or 1 provided that when R is hydrogen n is 1. Said compounds are useful cardiovascular agents.

  本发明涉及式化合物： 及其药学上可接受的盐 其中 Ar 相同或不同，代表苯基或卤素取代的苯基；R 选自低烷氧基或二（低烷基）氨基；R1 选自氢、低烷氧基羰基、羧基或低烷基氨基羰基；n 为 0 或 1，但当 R 为氢时，n 为 1。 上述化合物是有用的心血管药剂。
• Dicationic Electrophiles from Olefinic Amines in Superacid
  作者：Yun Zhang、Aaron McElrea、Gregorio V. Sanchez、Dat Do、Alma Gomez、Sharon L. Aguirre、Rendy、Douglas A. Klumpp

  DOI：10.1021/jo030024z

  日期：2003.6.1

  This paper describes the superacid-catalyzed chemistry of olefinic amines and related compounds. A variety of olefinic amines are found to react with benzene in CF3SO3H (triflic acid) to give addition products in good yields (75-99%), including the pharmaceutical agents fenpiprane and prozapine. A general mechanism is proposed that invokes the formation of reactive, dicationic electrophiles and the direct observation of a diprotonated species is reported from low-temperature NMR experiments. This chemistry is also used to conveniently prepare functionalized polystyrene beads having pendant amine groups.
• OHTAKA, HIROSHI;KANAZAWA, TOSHIRO;ITO, KEIZO;TSUKAMOTO, GORO, CHEM. AND PHARM. BULL., 35,(1987) N 11, 4637-4641
  作者：OHTAKA, HIROSHI、KANAZAWA, TOSHIRO、ITO, KEIZO、TSUKAMOTO, GORO

  DOI：——

  日期：——
• CYCLIC AMINE COMPOUNDS AND PEST CONTROL AGENT
  申请人：NIPPON SODA CO., LTD.

  公开号：EP1947098B1

  公开（公告）日：2011-11-30