4-ethoxy-1,4-dimethylpiperidine | 113728-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-ethoxy-1,4-dimethylpiperidine
• CAS: 113728-99-7
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: GMIGTOVEDGLSSY-UHFFFAOYSA-N

物化性质

• 沸点：
  170 °C(Press: 20 Torr)
• 密度：
  0.91±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-dimethyl-1,2,5,6-tetrahydropyridine 、 乙醇 以30%的产率得到
  参考文献：
  名称：

  SILHANKOVA A.; DAVIDOVA D.; SPUTOVA M.; TRSKA P.; VACULIKOVA D.; VLKOVA D+, COLLECT. CZECHOSL. CHEM. COMMUN., 52,(1987) N 5, 1298-1304

  摘要：

  DOI：

文献信息

• [EN] PYRIMIDINE, PYRIDINE AND TRIAZINE DERIVATIVES AS MAXI-K CHANNEL OPENERS.<br/>[FR] DÉRIVÉS DE PYRIMIDINE, PYRIDINE ET TRIAZINE EN TANT QU'OUVREURS DE CANAUX MAXI-K
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2009125870A1

  公开（公告）日：2009-10-15

  A compound of formula (A); wherein ring A is an aromatic ring or a heteroaromatic ring; R1 is independently halogen, cyano, etc., each of X1, X2 and X3 is CR2 or nitrogen, R2 is independently hydrogen, etc., n is 0, 1, 2, 3 or 4; -D-Y is -O-CH2COOH, etc, and G is a substituted amino, a substituted heterocyclic group, etc, or a pharmaceutical acceptable salt thereof, has activities of opening BK channels.

  化合物的结构式（A）；其中环A是芳香环或杂芳环；R1独立地是卤素、氰基等；X1、X2和X3中的每一个是CR2或氮，R2独立地是氢等；n为0、1、2、3或4；-D-Y是-O-CH2COOH等；G是取代氨基、取代杂环基等，或其药用可接受盐，具有开放BK通道的活性。
• 1,7-DIAZACARBAZOLES AND METHODS OF USE
  申请人：Dyke Hazel Joan

  公开号：US20110183938A1

  公开（公告）日：2011-07-28

  The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  该发明涉及1,7-二氮杂咔唑化合物的公式（I）、（I-a）和（I-b），它们可用作激酶抑制剂，更具体地用作检查点激酶1（CHK1）抑制剂，因此可用作癌症治疗剂。该发明还涉及包含这些化合物的组合物，更具体地是药物组合物，以及使用它们治疗各种癌症和高增殖性疾病的方法，以及使用这些化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。
• Silhankova, Alexandra; Davidova, Dagmar; Sputova, Michaela, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 5, p. 1298 - 1304
  作者：Silhankova, Alexandra、Davidova, Dagmar、Sputova, Michaela、Trska, Petr、Vaculikova, Dana、et al.

  DOI：——

  日期：——
• SILHANKOVA A.; DAVIDOVA D.; SPUTOVA M.; TRSKA P.; VACULIKOVA D.; VLKOVA D+, COLLECT. CZECHOSL. CHEM. COMMUN., 52,(1987) N 5, 1298-1304
  作者：SILHANKOVA A.、 DAVIDOVA D.、 SPUTOVA M.、 TRSKA P.、 VACULIKOVA D.、 VLKOVA D+

  DOI：——

  日期：——
• PYRIMIDINE, PYRIDINE AND TRIAZINE DERIVATIVES AS MAXI-K CHANNEL OPENERS
  申请人：Tsuzuki Yasuyuki

  公开号：US20110034435A1

  公开（公告）日：2011-02-10

  A compound of formula (A); wherein ring A is an aromatic ring or a heteroaromatic ring; R 1 is independently halogen, cyano, etc., each of X 1 , X 2 and X 3 is CR 2 or nitrogen, R 2 is independently hydrogens, etc., n is 0, 1, 2, 3 or 4; -D-Y is —O—CH 2 COOH, etc, and G is a substituted amino, a substituted heterocyclic group, etc, or a pharmaceutical acceptable salt thereof, has activities of opening BK channels.