8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan | 28286-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan
• 英文别名: 1-methylpiperidine-4-spiro-2'-dioxolane；8-methyl-1,4-dioxa-8-aza-spiro[4.5]decane；4,4-ethylenedioxy-1-methyl-piperidine；8-Methyl-1,4-dioxa-8-azaspiro<4,5>decan；8-Methyl-1,4-dioxa-8-azaspiro[4.5]decane
• CAS: 28286-05-7
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: YLPBUMOJYDPQJB-UHFFFAOYSA-N

物化性质

• 沸点：
  217.6±40.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan 在 氢氧化钾 、 potassium carbonate 作用下， 以 乙醇 、 苯 为溶剂， 生成 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone
  参考文献：
  名称：

  Neurotropic and psychotropic agents. LXVII. 1-[4,4-Bis(4-fluorophenyl)butyl]-4-hydroxy-4-(3-trifluoromethyl-4-chlorophenyl)piperidine and related compounds: New synthetic approaches

  摘要：

  DOI：

  10.1135/cccc19733879
• 作为产物：
  描述：

  1-甲基-4-哌啶酮盐酸盐 、 乙二醇 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 生成 8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan
  参考文献：
  名称：

  Neurotropic and psychotropic agents. LXVII. 1-[4,4-Bis(4-fluorophenyl)butyl]-4-hydroxy-4-(3-trifluoromethyl-4-chlorophenyl)piperidine and related compounds: New synthetic approaches

  摘要：

  DOI：

  10.1135/cccc19733879

文献信息

• [EN] CYCLOHEXENE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASE COMPRISING THE SAME AS ACTIVE INGREDIENT<br/>[FR] DÉRIVÉ DE CYCLOHEXÈNE, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE POUR PRÉVENIR OU TRAITER UNE MALADIE MÉTABOLIQUE, CONTENANT LEDIT DÉRIVÉ COMME PRINCIPE ACTIF
  申请人：HYUNDAI PHARM CO LTD

  公开号：WO2017078352A1

  公开（公告）日：2017-05-11

  The present invention relates to: a cyclohexene derivative; a preparation method thereof; and a pharmaceutical composition for preventing or treating metabolic disease comprising the same as an active ingredient. The cyclohexene derivative according to the present invention increases the intracellular activity of cyclic adenosine monophosphate (cAMP) by activating G protein-coupled receptor 119 (GPR-119) and simultaneously exhibits weight loss and hypoglycemic effects by inducing the release of glucagon-like peptide-1 (GLP-1), which is a neuroendocrine protein, and thus can be useful as a pharmaceutical composition for preventing or treating metabolic diseases such as obesity, type 1 diabetes, type 2 diabetes, inadequate glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia and syndrome X.

  本发明涉及：一种环己烯衍生物；其制备方法；以及一种包含该衍生物作为活性成分的用于预防或治疗代谢疾病的药物组合物。根据本发明的环己烯衍生物通过激活G蛋白偶联受体119（GPR-119）增加了细胞内环状腺苷一磷酸（cAMP）的活性，并通过诱导释放神经内分泌蛋白胰高血糖素样肽-1（GLP-1），同时表现出减肥和降糖效果，因此可作为预防或治疗诸如肥胖、1型糖尿病、2型糖尿病、葡萄糖耐量不足、胰岛素抵抗、高血糖、高脂血症、高甘油三酯血症、高胆固醇血症、血脂异常和综合征X等代谢疾病的药物组合物。
• Dioxanes and uses thereof
  申请人：——

  公开号：US20040072849A1

  公开（公告）日：2004-04-15

  In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): 1 and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 , R 3 , n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.

  鉴于需要开发新型治疗剂和有效的合成方法，本发明提供了一般式(I)的新化合物： 1 及其药学上可接受的衍生物，其中R 1 ，R 2 ，R 3 ，n，X和Y如本文所定义。本发明还提供了包含一种式(I)化合物和药学上可接受的载体的药物组合物。本发明还提供了能够抑制组蛋白去乙酰化酶活性的化合物以及治疗由组蛋白去乙酰化酶活性调节的疾病的方法（例如，癌症和原虫感染），包括向需要的受体施用一种式(I)化合物的治疗有效量。本发明还提供了调节Ure2p下游葡萄糖敏感基因子集的方法。本发明还提供了制备本发明化合物的方法。
• Synthesis and selective activity of cholinergic agents with rigid skeletons. II.
  作者：SHOJI TAKEMURA、YASUYOSHI MIKI、MARIKO HOSHIDA、MAYUMI SHIBANO、ARITOMO SUZUKI

  DOI：10.1248/cpb.29.3019

  日期：——

  Three types of compound, quinuclidine-3-spiro-2'-dioxolane (A), piperidine-4-spiro-2'-dioxolane (B), and piperidine-4-spiro-2'-(4'-oxodioxolane) (C) and their methiodides were synthesized. The cholinomimetic activities of these compounds were examined to investigate the relationship between the activities of these compounds, which have rigid skeletons, and those of known muscarinic agents.

  三种类型的化合物（喹宁环-3-螺-2'-二氧六环（A）、哌啶-4-螺-2'-二氧六环（B）和哌啶-4-螺-2'-(4'-氧二氧六环)（C））及其甲碘化物被合成。为了研究这些具有刚性骨架的化合物与已知毒蕈碱样作用剂之间活性的关系，对其胆碱能样活性进行了检验。
• CYCLOALKYLCARBAMATE BENZAMIDE ANILINE HDAC INHIBITOR COMPOUNDS
  申请人：Venkataramani Chandrasekar

  公开号：US20100311794A1

  公开（公告）日：2010-12-09

  The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.

  本发明提供了一种具有组蛋白去乙酰化酶（HDAC）抑制活性的一般式（I）化合物，包括该化合物的药物组合物，以及使用该化合物治疗疾病的方法。
• Novel Anthra [1, 2-d]imidazole-6,11-dione Derivatives, Preparation Method and application thereof
  申请人：HUANG Hsu-Shan

  公开号：US20110207719A1

  公开（公告）日：2011-08-25

  A series of novel anthra[1,2-d]imidazole-6,11-dione derivatives, and the preparation method and application of said derivatives, wherein said application includes a pharmaceutical composition containing said derivatives for treating cancer, and said application involves effects of said derivatives for inhibiting telomerase activity, inhibiting the growth of cancer cell, treating cancer and the like.

  一系列新型蒽[1,2-d]咪唑-6,11-二酮衍生物，以及所述衍生物的制备方法和应用，其中所述应用包括含有所述衍生物的用于治疗癌症的药物组合物，所述应用涉及所述衍生物抑制端粒酶活性、抑制癌细胞生长、治疗癌症等效果。