3-amino-6-<(2S)-2,3-dihydroxypropyl>-1,2,4-triazine | 143578-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 3-amino-6-<(2S)-2,3-dihydroxypropyl>-1,2,4-triazine
• 英文别名: 3-amino-6-((2S)-2,3-dihydroxypropyl)-1,2,4-triazine；(2S)-3-(3-amino-1,2,4-triazin-6-yl)propane-1,2-diol
• CAS: 143578-85-2
• 化学式: C₆H₁₀N₄O₂
• 分子量: 170.171
• InChiKey: CJOSEJXDAOGCDQ-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-deoxyxylosone 、 氨基胍媒染剂 以 水 为溶剂， 反应 0.08h， 以11.6%的产率得到3-amino-6-<(2S)-2,3-dihydroxypropyl>-1,2,4-triazine
  参考文献：
  名称：

  The reaction of 3-deoxy-d-glycero-pentos-2-ulose (“3-deoxyxylosone”) with aminoguanidine

  摘要：

  DOI：

  10.1016/0008-6215(91)80024-h

文献信息

• The reaction of some dicarbonyl sugars with aminoguanidine
  作者：Jan Hirsch、Eva Petrakova、Milton S. Feather

  DOI：10.1016/s0008-6215(00)90999-6

  日期：1992.7

  The reactions of aminoguanidine (guanylhydrazine) with 3-deoxy-D-erythro-hexos-2-ulose (1a), 3-deoxy-D-glycero-pentose-2-ulose (1b), D-erythro-hexos-2-ulose (1c), and D-glycero-pentose-2-ulose (1d) were examined at 37-degrees at a solution pH of 7.0 (phosphate buffer). For 1a and 1b, two major products were observed and shown respectively to be the 5- and 6-substituted 3-amino-1,2,4-triazine derivatives. The ratios of the products were independent of the amount of aminoguanidine present or the order of mixing the reagents prior to the experiments. For 1c and 1d, only the 5-substituted triazine derivatives were formed, No evidence for hydrazone or bishydrazone formation was observed.
• The reaction of 3-deoxy-d-glycero-pentos-2-ulose (“3-deoxyxylosone”) with aminoguanidine
  作者：Jan Hirsch、John W. Bayness、James A. Blackledge、Milton S. Feather

  DOI：10.1016/0008-6215(91)80024-h

  日期：1991.11