tributyl (cyclobutyloxymethyl)tin | 393863-17-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 英文名称: tributyl (cyclobutyloxymethyl)tin
• 英文别名: tributylcyclobutoxymethyltin；Tributyl-cyclobutoxymethyl-tin；tributyl(cyclobutyloxymethyl)stannane
• CAS: 393863-17-7
• 化学式: C₁₇H₃₆OSn
• 分子量: 375.182
• InChiKey: AJMCPPHFXMZWCK-UHFFFAOYSA-N

物化性质

• 沸点：
  364.9±44.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.94
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tributyl (cyclobutyloxymethyl)tin 在 正丁基锂 、 硼酸三异丙酯 、 potassium hydrogen difluoride 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.91h， 以42%的产率得到(cyclobutoxymethyl)trifluoro- λ⁴-borane potassium salt
  参考文献：
  名称：

  HYDROXYMETHYLBORON COMPOUNDS

  摘要：

  公开号：

  EP1867650B1
• 作为产物：
  描述：

  环丁醇 、 三丁基(碘甲基)锡烷 以 四氢呋喃 、 乙酸乙酯 为溶剂， 生成 tributyl (cyclobutyloxymethyl)tin
  参考文献：
  名称：

  Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors

  摘要：

  本发明涉及式(I)的三环2-吡啶酮化合物，或其立体异构体形式、立体异构体混合物或其药用可接受盐形式，这些化合物可用作HIV反转录酶的抑制剂，以及包含它们的药物组合物和诊断试剂盒，以及用于治疗病毒感染或作为检测标准或试剂的方法。

  公开号：

  US20020107261A1

文献信息

• Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
  申请人：——

  公开号：US20020107261A1

  公开（公告）日：2002-08-08

  The present invention relates to tricyclic 2-pyridone compounds of formula (I): 1 or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

  本发明涉及式(I)的三环2-吡啶酮化合物，或其立体异构体形式、立体异构体混合物或其药用可接受盐形式，这些化合物可用作HIV反转录酶的抑制剂，以及包含它们的药物组合物和诊断试剂盒，以及用于治疗病毒感染或作为检测标准或试剂的方法。
• Heterocycles substituted pyridine derivatives and antifungal agent containing thereof
  申请人：Tanaka Keigo

  公开号：US20070105904A1

  公开（公告）日：2007-05-10

  An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R 1 represents a hydrogen atom, a halogen atom, an amino group, a C 1-6 alkyl group, a C 1-6 alkoxy group or a C 1-6 alkoxy C 1-6 alkyl group; R 2 represents a hydrogen atom, a C 1-6 alkyl group, an amino group or a di C 1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C 1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH 2 O—, —OCH 2 —, —NH—, —CH 2 NH—, —NHCH 2 —, —CH 2 S—, or —SCH 2 —; R 3 represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 3-8 cycloalkyl group, a C 6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R 4 represents a hydrogen atom or a halogen atom.

  本发明的目的是提供一种具有优异的抗真菌效果、在物理性质、安全性和代谢稳定性方面优越的抗真菌剂。根据本发明，公开了以下式(I)所表示的化合物或其盐：其中，R1表示氢原子、卤素原子、氨基、C1-6烷基、C1-6烷氧基或C1-6烷氧基C1-6烷基；R2表示氢原子、C1-6烷基、氨基或二C1-6烷基氨基；X和Y中的一个是氮原子，另一个是氮原子或氧原子；环A表示一个5-或6-成员杂芳环或苯环，可以有一个卤素原子或1或2个C1-6烷基；Z表示单键、亚甲基、乙烯基、氧原子、硫原子、—CH2O—、—OCH2—、—NH—、—CH2NH—、—NHCH2—、—CH2S—或—SCH2—；R3表示氢原子、卤素原子、C1-6烷基、C3-8环烷基、C6-10芳基、5-或6-成员杂芳基或5-或6-成员非芳杂环基，可以有1或2个取代基；R4表示氢原子或卤素原子。
• Oxymethyl Boron Compounds
  申请人：Tanaka Keigo

  公开号：US20080242859A1

  公开（公告）日：2008-10-02

  The present invention provides compounds which are useful as safe substitutes for the organotin reagent used in coupling reaction for the oxymethylation of aromatic rings, such as alkoxymethylation or hydroxymethylation, with a palladium catalyst and which can dispense with chromatographic purification with silica gel in the production and are suitable for mass production; and compounds applicable even to the oxymethylation of aromatic ring substrates which do not permit coupling reaction by conventional technique or have low reactivity.

  本发明提供了一些化合物，可用作在钯催化下进行含氧甲基化反应（如烷氧甲基化或羟基甲基化）的偶联反应中，有机锡试剂的安全替代品。这些化合物可在生产中省去硅胶色谱纯化步骤，并适用于大规模生产；并且这些化合物适用于那些传统技术无法进行偶联反应或反应活性较低的芳环基底物的含氧甲基化反应。
• PYRIDINE DERIVATIVES SUBSTITUTED BY HETEROCYCLIC RING AND PHOSPHONOAMINO GROUP, AND ANTI-FUNGAL AGENT CONTAINING SAME
  申请人：Tanaka Keigo

  公开号：US20090082403A1

  公开（公告）日：2009-03-26

  Anti-fungal agent having excellent anti-fungal action physicochemical properties including safety and water solubility. Compound represented by formula (I), or salt thereof: wherein R 1 represents hydrogen, halogen, amino, R 11 —NH— wherein R 11 represents C 1-6 alkyl, hydroxy C 1-6 alkyl, C 1-6 alkoxy C 1-6 alkyl, or C 1-6 alkoxycarbonyl C 1-6 alkyl, R 12 —(CO)—NH— wherein R 12 represents C 1-6 alkyl group or C 1-6 alkoxy C 1-6 alkyl, C 1-6 alkyl, hydroxy C 1-6 alkyl, cyano C 1-6 alkyl, C 1-6 alkoxy, or C 1-6 alkoxy C 1-6 alkyl or a phosphonoamino group; R 2 represents hydrogen, C 1-6 alkyl, amino, or a di C 1-6 alkylamino group or a phosphonoamino group; one of X and Y is nitrogen while the other is nitrogen or oxygen; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom or 1 or 2 C 1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, oxygen, sulfur, —CH 2 O—, —OCH 2 —, —NH—, —CH 2 NH—, —NHCH 2 —, —CH 2 S—, or —SCH 2 —; R 3 represents hydrogen or halogen or C 1-6 alkyl, C 3-8 cycloalkyl, C 6-10 aryl, a 5- or 6-member heteroaryl group or a 5- or 6-member nonaromatic heterocyclic group which may have 1 or 2 substituents; and R 4 represents hydrogen or halogen; provided that either R 1 or R 2 represents a phosphonoamino group.

  具有优异的抗真菌作用、安全性和水溶性的抗真菌剂。化合物的化学式（I）或其盐：其中R1代表氢、卤素、氨基、R11-NH-，其中R11代表C1-6烷基、羟基C1-6烷基、C1-6烷氧基C1-6烷基或C1-6烷氧羰基C1-6烷基，R12-(CO)-NH-，其中R12代表C1-6烷基或C1-6烷氧基C1-6烷基、C1-6烷基、羟基C1-6烷基、氰基C1-6烷基、C1-6烷氧基或C1-6烷氧基C1-6烷基或磷酸氨基基团；R2代表氢、C1-6烷基、氨基或二C1-6烷基氨基基团或磷酸氨基基团；X和Y中的一个是氮，另一个是氮或氧；环A代表一个5-或6-成员的杂芳环或苯环，可能具有卤素原子或1或2个C1-6烷基基团；Z代表单键、亚甲基、乙烯基、氧、硫、-CH2O-、-OCH2-、-NH-、-CH2NH-、-NHCH2-、-CH2S-或-SCH2-；R3代表氢、卤素或C1-6烷基、C3-8环烷基、C6-10芳基、一个5-或6-成员的杂芳基团或一个5-或6-成员的非芳香杂环基团，可能具有1或2个取代基；R4代表氢或卤素；但要求R1或R2中的一个代表磷酸氨基基团。
• HETEROCYCLES SUBSTITUTED PYRIDINE DERIVATIVES AND ANTIFUNGAL AGENT CONTAINING THEREOF
  申请人：TANAKA Keigo

  公开号：US20120029023A1

  公开（公告）日：2012-02-02

  An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R 1 , R 2 , X, Y, ring A, Z, R 3 and R 4 are as defined in the specification.

  本发明的目的是提供一种具有优异的抗真菌效果且在物理性质、安全性和代谢稳定性方面优越的抗真菌剂。根据本发明，公开了下式（I）所表示的化合物或其盐：其中R1、R2、X、Y、环A、Z、R3和R4如规范中所定义。