N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfamoyl]-2-hydroxybenzamide | 873556-29-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfamoyl]-2-hydroxybenzamide
• CAS: 873556-29-7
• 化学式: C₁₇H₁₉N₇O₇S
• 分子量: 465.4
• InChiKey: CHPCUEVDLWQUFT-CNEMSGBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  223
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• Anthranilyl-adenosinemonosulfamate analogs and uses thereof
  申请人：Memorial Sloan-Kettering Cancer Center

  公开号：US10874686B2

  公开（公告）日：2020-12-29

  Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or of an infectious disease (e.g., bacterial infection (e.g., P. aeruginosa infection).

  本文提供了式（I）化合物及其药物可接受盐、溶液剂、水合物、多晶体、共晶体、同系物、立体异构体和原药。还提供了涉及本发明化合物的药物组合物、试剂盒和方法，用于治疗和/或传染性疾病（如细菌感染（如绿脓杆菌感染））。
• ANTHRANILYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF
  申请人：Memorial Slooan-Kettering Cancer Center

  公开号：US20190038656A1

  公开（公告）日：2019-02-07

  Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or of an infectious disease (e.g., bacterial infection (e.g., P. aeruginosa infection).