5-(2-(6-azabicyclo[4.2.0]octyl)ethynyl)isoxazole | 651314-05-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-(2-(6-azabicyclo[4.2.0]octyl)ethynyl)isoxazole
• 英文别名: 1-Azabicyclo[4.2.0]octane, 6-(5-isoxazolylethynyl)-；5-[2-(1-azabicyclo[4.2.0]octan-6-yl)ethynyl]-1,2-oxazole
• CAS: 651314-05-5
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.256
• InChiKey: UXZHLSLHJNIGRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] FIVE-MEMBERED HETEROAROMATIC OLEFINIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NCOTINIC CHOLINERGIC RECEPTORS<br/>[FR] COMPOSES HETEROAROMATIQUES OLEFINIQUES AZACYCLIQUES A CINQ ELEMENTS, COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITS COMPOSES ET LEUR UTILISATION COMME INHIBITEURS DES RECEPTEURS NICOTINIQUES CHOLINERGIQUES
  申请人：TARGACEPT INC

  公开号：WO2004009599A1

  公开（公告）日：2004-01-29

  The present invention relates to five-membered heteroaromatic olefinic azacyclic compounds and five-membered heteroaromatic acetylenic azacylic compounds, having formula (I) wherein the ring including X, XI, XII, XIII and X IV is heteroaromatic, B is a two-carbon bridging species and Q, E, EI, EII, EIII, m and n are as defined herein and pharmaceutical compositions containing them that are capable of affecting nicotic cholinergic receptors.

  本发明涉及五元杂芳烯基氮杂环化合物和五元杂芳乙炔基氮环化合物，其化学式为（I），其中包括X、XI、XII、XIII和XIV的环是杂芳环，B是一个含有两个碳的桥联物种，Q、E、EI、EII、EIII、m和n的定义如本文所述，并含有这些化合物的药物组合物，能够影响烟碱型胆碱受体。
• Pharmaceutical compositions and methods for use
  申请人：——

  公开号：US20020160998A1

  公开（公告）日：2002-10-31

  The present invention relates to aryl olefinic azacyclic compounds and aryl acetylenic azacylic compounds. The present invention relates in particular to five-membered heteroaromatic olefinic azacyclic compounds and five-membered heteroaromatic acetylenic azacylic compounds, including isoxazolyl olefinic cycloalkylamines and isoxazolyl acetylenic cycloalkylamines.

  本发明涉及芳基烯烃氮杂环化合物和芳基乙炔基氮杂环化合物。本发明特别涉及五元杂环芳基烯烃氮杂环化合物和五元杂环芳基乙炔基氮杂环化合物，包括异噁唑烯烃环烷胺和异噁唑基乙炔基环烷胺。
• Insulated electrical coil having enhanced oxidation resistant polymeric insulation composition
  申请人：Siemens Westinghouse Power Corporation

  公开号：US20030044605A1

  公开（公告）日：2003-03-06

  An insulated electrical coil is disclosed and is formed from a plurality of turns of coil, each having a cured body of resinous insulation applied to each turn of coil. The insulation is formed from a cured resinous composition of epoxy-anhydride resin that has been prereacted with an antioxidant oligomer selected from the group consisting of organophosphorus compounds, sterically-hindered alkylated phenolics, alkyl and aryl thio-esters, alkyl and aryl thio-phosphites, thiazoles, lactones, hydroxylamines, and maleimides.

  本发明公开了一种绝缘线圈，它由多圈线圈组成，每圈线圈上都有一个树脂绝缘固化体。绝缘体由环氧酸酐树脂的固化树脂组合物形成，该树脂组合物已与抗氧化剂低聚物发生预反应，抗氧化剂低聚物选自有机磷化合物、立体受阻的烷基化酚、烷基和芳基硫代酯、烷基和芳基硫代磷酸酯、噻唑、内酯、羟胺和马来酰亚胺组成的组。
• US6680119B2
  申请人：——

  公开号：US6680119B2

  公开（公告）日：2004-01-20