5-Chloro-2-thiophenecarbothioic acid | 1807562-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-Chloro-2-thiophenecarbothioic acid
• 英文别名: 5-chlorothiophene-2-carbothioic S-acid
• CAS: 1807562-61-3
• 化学式: C₅H₃ClOS₂
• 分子量: 178.7
• InChiKey: KSZRKQZHNWPBAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] A PROCESS FOR PREPARING RIVAROXABAN OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE RIVAROXABAN OU D'UN SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CE DERNIER
  申请人：WOCKHARDT LTD

  公开号：WO2015104605A1

  公开（公告）日：2015-07-16

  The present invention relates to a process for the preparation of Rivaroxaban and its novel intermediates, or pharmaceutically acceptable salts thereof. The present invention provides novel intermediates, which may be useful for the preparation of Rivaroxaban or its pharmaceutically acceptable salts thereof. The process of preparation by using novel intermediate is very simple cost effective and may be employed at commercial scale. The product obtained by using novel intermediate yield the Rivaroxaban of purity 99% or more, when measured by HPLC. The present invention especially relates to a process for the preparation of Rivaroxaban from thioester of formula II, or a pharmaceutically acceptable salt thereof, wherein R is leaving group.

  本发明涉及一种用于制备利伐沙班及其新型中间体或其药学上可接受的盐的过程。本发明提供了新型中间体，可用于制备利伐沙班或其药学上可接受的盐。使用新型中间体的制备过程非常简单，成本效益高，可在商业规模上应用。使用新型中间体得到的产品，其纯度可通过HPLC测量达到99％或更高。本发明特别涉及一种从公式II的硫代酯或其药学上可接受的盐制备利伐沙班的过程，其中R是离去基团。