3-[1-(trifluoroacetyl)-4-piperidinyl]-4-methoxyaniline | 648901-48-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-[1-(trifluoroacetyl)-4-piperidinyl]-4-methoxyaniline
• 英文别名: 1-[4-(5-Amino-2-methoxyphenyl)piperidin-1-yl]-2,2,2-trifluoroethan-1-one；1-[4-(5-amino-2-methoxyphenyl)piperidin-1-yl]-2,2,2-trifluoroethanone
• CAS: 648901-48-8
• 化学式: C₁₄H₁₇F₃N₂O₂
• 分子量: 302.296
• InChiKey: REOKKVHTABJLGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED BENZANILIDES AS MODULATORS OF THE CCR5 RECEPTOR<br/>[FR] BENZANILIDES SUBSTITUES UTILISES EN TANT QUE MODULATEURS DU RECEPTEUR CCR5
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004011427A2

  公开（公告）日：2004-02-05

  This invention relates to substituted benzanilides which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders (for example, atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis and other fibrotic diseases, atherosclerosis, psoriasis, autoimmune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted benzanilides which are CCR5 receptor antagonists. Furthermore, since CD8+ T cells have been implicated in COPD, CCR5 may play a role in their recruitment and therefore antagonists to CCR5 could provide potential therapeutic in the treatment of COPD. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor modulators may be useful in the treatment of HIV infection.