1-(4,5-Dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2,3-dihydro-1H-tetrazol-1-ium bromide | 402789-90-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 1-(4,5-Dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2,3-dihydro-1H-tetrazol-1-ium bromide
• 英文别名: 2-(2,5-diphenyl-1,3-dihydrotetrazol-1-ium-1-yl)-4,5-dimethyl-1,3-thiazole;bromide
• CAS: 402789-90-6
• 化学式: C18H18BrN5S
• 分子量: 416.3
• InChiKey: NEMYGKLAKGMLPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.42
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Pyridopyridazine compounds and their use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0491477A1

  公开（公告）日：1992-06-24

  An assay method which comprises utilizing chemiluminescence of a pyridopyridazine compound of the formula wherein R₁ is a hydrocarbon group or a heterocyclic group each of which may be substituted and R₂ is hydroxy group, thiol group, amino group or a monosubstituted amino group, and when R₂ is a monosubstituted amino group, R₂ may be taken together with R₁ to form the ring; R₃ is hydrogen atom, a hydroxy group which may be substituted, an amino group which may be substituted, a thiol group which may be substituted, a halogen atom, a heterocyclic group, nitro group, cyano group, carboxyl group which may be esterified or amidated, azido group, sulfo group or an organic sulfonyl group, provided that when R₁ is an aliphalic group, R₃ is not hydrogen atom; and X is oxygen atom or sulfur atom,or a salt thereof; and a novel compound of the formula (I) wherein the symbols are as defined above with proviso that when R₃ is a hydrogen atom, R₁ is a substituted aryl group or a heterocyclic group which may be substituted,or a salt thereof and the production methods thereof.

  一种检测方法，包括利用化学发光法检测式中的哒嗪化合物 其中 R₁ 是烃基或杂环基，每个烃基或杂环基均可被取代，R₂ 是羟基、硫醇基、氨基或单取代氨基，当 R₂ 是单取代氨基时，R₂ 可与 R₁ 一起形成环；R₃ 是氢原子、可被取代的羟基、可被取代的氨基、可被取代的硫醇基、卤素原子、杂环基、硝基、氰基、可被酯化或酰胺化的羧基、叠氮基、磺基或有机磺酰基，但当 R₁ 是脂环族基团时，R₃ 不是氢原子；和 X 是氧原子或硫原子，或其盐类；以及式（I）的新型化合物，其中符号如上定义，但当 R₃ 是氢原子时，R₁ 是取代的芳基或可被取代的杂环基团，或其盐类及其生产方法。
• Glia activating factor (GAF), antibodies against it and their uses
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0608546A2

  公开（公告）日：1994-08-03

  The present invention relates to a glia activating factor (GAF) in which 33 to 49 N-terminal amino acids are deleted from the N-terminus of the GAF polypeptide of SEQ ID NO: 3, as well as an anti-GAF antibody which is highly sensitive to assay the GAF and is capable of neutralizing GAF's activity, is produced. Using the antibody, GAF and its biological activity can be assayed easily with high sensitivity. Further, the neutralizing antibody can be expected to have preventive and curative effects on diseases caused by GAF's excessive action. Furthermore, the GAF polypeptide disclosed herein is more stable to acids and heat than the conventional GAFs, therefore, it can be used as a platelet-increasing agent, etc., more advantageously than the previously known GAFs.

  本发明涉及一种从 SEQ ID NO: 3 的 GAF 多肽的 N 端删除了 33 至 49 个 N 端氨基酸的神经胶质激活因子（GAF），以及一种对 GAF 检测灵敏度高并能中和 GAF 活性的抗 GAF 抗体。 使用该抗体，可以方便、高灵敏度地检测 GAF 及其生物活性。此外，中和抗体可望对 GAF 过度作用引起的疾病产生预防和治疗效果。此外，与传统的 GAF 相比，本发明公开的 GAF 多肽对酸和热更稳定，因此，与以前已知的 GAF 相比，本发明公开的 GAF 多肽更有利于用作血小板增加剂等。
• MONOCLONAL ANTIBODY, HYBRIDOMAS, THEIR PRODUCTION AND USE
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0507948A1

  公开（公告）日：1992-10-14
• A METHOD FOR ASSAYING THE ACTIVITY OF SPERMIDINE/SPERMINE N1-ACETYLTRASFERASE
  申请人：BioMark Technologies Inc.

  公开号：EP2788498A1

  公开（公告）日：2014-10-15
• SPERMIDINE/SPERMINE N'-ACETYLTRANSFERASE SUBSTRATES AS ANTI-CANCER DRUG COMPOUNDS
  申请人：BioMark Technologies Inc.

  公开号：EP2928458A1

  公开（公告）日：2015-10-14