N,N-Diethyl-4-{(E)-[4-(methanesulfonyl)phenyl]diazenyl}aniline | 32044-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: N,N-Diethyl-4-{(E)-[4-(methanesulfonyl)phenyl]diazenyl}aniline
• 英文别名: N,N-diethyl-4-[(4-methylsulfonylphenyl)diazenyl]aniline
• CAS: 32044-90-9
• 化学式: C₁₇H₂₁N₃O₂S
• 分子量: 331.439
• InChiKey: LHPKICBFTUQJAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  70.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-Diethyl-4-{(E)-[4-(methanesulfonyl)phenyl]diazenyl}aniline 、 5,11,17,23,29,35,41,47-octasulfonato-49,50,51,52,53,54,55,56-octakis<(S)-2-methylbutoxy>calix<8>arene 以 水 为溶剂， 生成
  参考文献：
  名称：

  New water-soluble host calixarenes bearing chiral substituents

  摘要：

  Chiral p-sulfonatocalix[n]arenes (n = 4, 6, and 8) bearing (S)-2-methylbutoxy groups (1(n)) have been synthesized. 1(n = 4) gave a simple, positive CD band, whereas 1(n = 6) and 1(n = 8) gave split CD bands characteristic of an exciton coupling at 1L(a) region. The sign (positive first Cotton effect and negative second Cotton effect) indicates that the chirality of excitons in these calixarenes is arranged in a clockwise direction. The difference between 1(n = 4) and the larger calixarenes 1(n = 6) and 1(n = 8) is accounted for by the difference in the ring rigidity: that is, 1(n = 6) nad 1(n = 8) are flexible enough to allow interactions of excitons in the excited state, whereas 1(n = 4) is too rigid to allow the interactions. On the addition of guest molecules (aliphatic alcohols) the CD band of 1(n = 4) was scarcely changed, whereas those of 1(n = 6) and 1(n = 8) were weakened. This result, together with the H-1 NMR data, suggests that the conformational fluctuation in 1(n = 6) and 1(n = 8) is considerably suppressed upon inclusion of these guest molecules. In the presence of 1(n = 6) or 1(n = 8) ICD bands were also observed for certain dye molecules (e.g., 4-cyano-4'-(diethylamino)azobenzene and 4-nitro-4'-(diethylamino)azobenzene). Careful comparison of the ICD spectra with the absorption spectra established that the calixarene complexes having 2:1 guest/calixarene stoichiometry are ICD-active whereas those having 1:1 guest/calixarene stoichiometry are ICD-silent. Interestingly, the sign of the Cotton effect showed that 4-cyano-4'-(diethylamino)azobenzene included in 1(n = 6) gives a counterclockwise exciton coupling, whereas that included in 1(n = 8) gives a clockwise exciton coupling. Thus, the present study demonstrates that the CD spectral technique is very useful to obtain insights into calixarene conformations and calixarene complexation properties.

  DOI：

  10.1021/jo00001a057

文献信息

• New water-soluble host calixarenes bearing chiral substituents
  作者：Takashi Arimura、Hirosuke Kawabata、Tsutomu Matsuda、Tsuyoshi Muramatsu、Hiroshi Satoh、Kazunari Fujio、Osamu Manabe、Seiji Shinkai

  DOI：10.1021/jo00001a057

  日期：1991.1

  Chiral p-sulfonatocalix[n]arenes (n = 4, 6, and 8) bearing (S)-2-methylbutoxy groups (1(n)) have been synthesized. 1(n = 4) gave a simple, positive CD band, whereas 1(n = 6) and 1(n = 8) gave split CD bands characteristic of an exciton coupling at 1L(a) region. The sign (positive first Cotton effect and negative second Cotton effect) indicates that the chirality of excitons in these calixarenes is arranged in a clockwise direction. The difference between 1(n = 4) and the larger calixarenes 1(n = 6) and 1(n = 8) is accounted for by the difference in the ring rigidity: that is, 1(n = 6) nad 1(n = 8) are flexible enough to allow interactions of excitons in the excited state, whereas 1(n = 4) is too rigid to allow the interactions. On the addition of guest molecules (aliphatic alcohols) the CD band of 1(n = 4) was scarcely changed, whereas those of 1(n = 6) and 1(n = 8) were weakened. This result, together with the H-1 NMR data, suggests that the conformational fluctuation in 1(n = 6) and 1(n = 8) is considerably suppressed upon inclusion of these guest molecules. In the presence of 1(n = 6) or 1(n = 8) ICD bands were also observed for certain dye molecules (e.g., 4-cyano-4'-(diethylamino)azobenzene and 4-nitro-4'-(diethylamino)azobenzene). Careful comparison of the ICD spectra with the absorption spectra established that the calixarene complexes having 2:1 guest/calixarene stoichiometry are ICD-active whereas those having 1:1 guest/calixarene stoichiometry are ICD-silent. Interestingly, the sign of the Cotton effect showed that 4-cyano-4'-(diethylamino)azobenzene included in 1(n = 6) gives a counterclockwise exciton coupling, whereas that included in 1(n = 8) gives a clockwise exciton coupling. Thus, the present study demonstrates that the CD spectral technique is very useful to obtain insights into calixarene conformations and calixarene complexation properties.