3-氨基-4-(N-丙基磺酰基)噻吩-2-羧酸 | 175201-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 中文名称: 3-氨基-4-(N-丙基磺酰基)噻吩-2-羧酸
• 英文名称: 3-Amino-4-propylsulfonylthiophene-2-carboxylic acid
• CAS: 175201-91-9
• 化学式: C₈H₁₁NO₄S₂
• 分子量: 249.3
• InChiKey: GLGDZBUCEUWQMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  548.0±50.0 °C(Predicted)
• 密度：
  1.479±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

文献信息

• [EN] NEW PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY<br/>[FR] NOUVEAUX DERIVES PYRIMIDONE A ACTIVITE ANTIFONGIQUE
  申请人：J. URIACH & CIA. S.A.

  公开号：WO1997005130A1

  公开（公告）日：1997-02-13

  (EN) Compounds of general formula (I) and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these compounds and processes for their preparation are also provided.(FR) Les composés de la formule générale (I) et leurs sels et solvates sont des agents antifongiques. Il sont utiles pour le traitement de différentes infections fongiques. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et des procédés permettant leur préparation.

  化合物的一般式（I）及其盐和溶剂物是抗真菌剂，因此可用于治疗各种真菌感染。还提供了包括这些化合物的制药组合物和其制备方法。
• Antibody purification
  申请人：Johansson Bo-Lennart

  公开号：US20070112178A1

  公开（公告）日：2007-05-17

  The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-modal ligand comprises at least one cation-exchanging group and at least one aromatic or heteroaromatic ring system. In one embodiment, the ring-forming atoms of the aromatic or hereoaromatic entity are selected among C, S or O, and the cation exchanging group is a weak cation exchanger. The present method may be used as a single step procedure or as a polishing step following a capture on a Protein A column.

  本发明涉及一种从溶液中分离抗体与污染物的方法，该方法包括将溶液与由支持物质和多模态配体组成的层析树脂接触，其中多模态配体包括至少一个阳离子交换基团和至少一个芳香或杂芳环系统。在一种实施方式中，芳香或杂芳实体的环形成原子被选择为C、S或O，而阳离子交换基团是弱阳离子交换剂。该方法可以作为单步程序或在蛋白A柱捕获后进行精加工步骤。
• Process for the purification of antibodies
  申请人：Johansson Bo-Lennart

  公开号：US20070167613A1

  公开（公告）日：2007-07-19

  The present invention relates to a process for the purification of antibodies from one or more impurities in a liquid, which process comprises contacting said liquid with a first chromatography resin comprised of a support to which multi-modal ligands have been immobilised to adsorb the antibodies to the resin, wherein each multi-modal ligand comprises at least one cation-exchanging group and at least one aromatic or heteroaromatic ring system; adding an eluent to release the antibodies from the resin; and contacting the eluate so obtained with a second chromatography resin. In one embodiment, the ring-forming atoms of the aromatic or heteroaromatic entity are selected from the group consisting of C, S and O, and the cation exchanging group is a weak cation exchanger.

  本发明涉及一种从液体中纯化抗体并去除一种或多种杂质的方法，该方法包括将所述液体与第一色谱树脂接触，该色谱树脂由支持体和多模态配体组成，其中每个多模态配体包括至少一个阳离子交换基团和至少一个芳香或杂芳环系统，以吸附抗体到树脂上；加入洗脱剂以从树脂中释放抗体；并将所得的洗脱物与第二色谱树脂接触。在一种实施例中，芳香或杂芳实体的环形原子选择自C、S和O组成的群体，并且阳离子交换基团是弱阳离子交换剂。
• PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0783501B1

  公开（公告）日：2001-01-10
• NEW PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0783501A1

  公开（公告）日：1997-07-16