3-chloro-1-(trimethylsilyl)-3-heptenone | 163010-48-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 3-chloro-1-(trimethylsilyl)-3-heptenone
• 英文别名: 3-Chloro-1-(trimethylsilyl)hept-3-EN-1-one；3-chloro-1-trimethylsilylhept-3-en-1-one
• CAS: 163010-48-8
• 化学式: C₁₀H₁₉ClOSi
• 分子量: 218.799
• InChiKey: CMISHGUTXBMMBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.75
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  硅烷,(3-氯-1-羰基-2-庚烯基)三甲基-,(E)- 反应 1.0h， 生成 3-chloro-1-(trimethylsilyl)-3-heptenone
  参考文献：
  名称：

  A conjugate addition-elimination route to alkenoyltrimethylsilanes

  摘要：

  Monosubstitution of 3,3-dichloro-1-(trimethylsilyl)2-propenone (1) with organocuprates stereoselectively affords E-3-alkyl- and Z-3-phenyl-3-chloro-1-(trimethylsilyl)-2-propenones. Further substitution proceeds stereoselectively as a function of extant and incoming substituents. 1 was also reduced to E-3-chloro-1-(trimethylsilyl)-2-propenone and the latter converted to E-3-alkyl- and E-3-phenyl-1-(trimethylsilyl)-2-propenones.

  DOI：

  10.1016/0040-4020(95)00561-l

文献信息

• A conjugate addition-elimination route to alkenoyltrimethylsilanes
  作者：Robert F. Cunico、Cui-ping Zhang

  DOI：10.1016/0040-4020(95)00561-l

  日期：1995.1

  Monosubstitution of 3,3-dichloro-1-(trimethylsilyl)2-propenone (1) with organocuprates stereoselectively affords E-3-alkyl- and Z-3-phenyl-3-chloro-1-(trimethylsilyl)-2-propenones. Further substitution proceeds stereoselectively as a function of extant and incoming substituents. 1 was also reduced to E-3-chloro-1-(trimethylsilyl)-2-propenone and the latter converted to E-3-alkyl- and E-3-phenyl-1-(trimethylsilyl)-2-propenones.