1,1-Dibutoxypropan-1-OL | 198333-82-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 原羧酸衍生物
• 英文名称: 1,1-Dibutoxypropan-1-OL
• 英文别名: 1,1-dibutoxypropan-1-ol
• CAS: 198333-82-3
• 化学式: C₁₁H₂₄O₃
• 分子量: 204.31
• InChiKey: WZOKCKHIBHOKGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Polyethylene glycol derivative and preparation method thereof
  申请人：Hanmi Fine Chemical Co., Ltd.

  公开号：US11168180B2

  公开（公告）日：2021-11-09

  The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol derivative which can be utilized in various ways as a drug linker, and is appropriate and effective for mass production and is advantageous in reproducible mass production of high-quality products.

  本发明涉及聚乙二醇衍生物及其制备方法。根据本发明的聚乙二醇衍生物的制备过程，可以提供一种新型聚乙二醇衍生物，可以作为药物连接剂在各种方面得到利用，适用于大规模生产，有利于高质量产品的可重复生产。
• METHOD FOR PREPARING POLYETHYLENE GLYCOL DIALDEHYDE DERIVATIVE
  申请人：Hanmi Fine Chemical Co., Ltd.

  公开号：EP3421521A1

  公开（公告）日：2019-01-02

  The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.

  本发明涉及一种改进的高纯度聚乙二醇二醛衍生物的制备方法。该制备方法以聚乙二醇甲磺酸盐与二烷氧基-1-丙醇反应制备的聚乙二醇二缩醛为中间体，可提供纯度高、末端活性强的聚乙二醇二醛衍生物，适合用作医药原料。
• POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREOF
  申请人：Hanmi Fine Chemical Co., Ltd.

  公开号：EP3708561A2

  公开（公告）日：2020-09-16

  The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol derivative which can be utilized in various ways as a drug linker, and is appropriate and effective for mass production and is advantageous in reproducible mass production of high-quality products.

  本发明涉及一种聚乙二醇衍生物及其制备方法。根据本发明的聚乙二醇衍生物的制备方法，可以提供一种新型的聚乙二醇衍生物，该衍生物可以以各种方式用作药物连接剂，并且适合于大规模生产，效果显著，有利于高质量产品的可重复性大规模生产。
• Method for preparing polyethylene glycol dialdehyde derivative
  申请人：Hanmi Fine Chemical Co., Ltd.

  公开号：US10781285B2

  公开（公告）日：2020-09-22

  The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.

  本发明涉及一种改进的高纯度聚乙二醇二醛衍生物的制备方法。该制备方法以聚乙二醇甲磺酸盐与二烷氧基-1-丙醇反应制备的聚乙二醇二缩醛为中间体，可提供纯度高、末端活性强的聚乙二醇二醛衍生物，适合用作医药原料。
• Method For Preparing Polyethylene Glycol Dialdehyde Derivative
  申请人：Hanmi Fine Chemical Co., Ltd.

  公开号：US20190040196A1

  公开（公告）日：2019-02-07

  The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.