Vevorisertib | 1416775-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Vevorisertib
• 英文别名: N-[1-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-5-yl]phenyl]piperidin-4-yl]-N-methylacetamide
• CAS: 1416775-46-6
• 化学式: C₃₅H₃₈N₈O
• 分子量: 586.7
• InChiKey: NZDSLYATTDIDPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  44
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Compositions and Methods for Treating Proliferation Disorders
  申请人：Arqule, Inc.

  公开号：US20160067260A1

  公开（公告）日：2016-03-10

  The present invention relates to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-(3-morpholinophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or N-(1-(3-(3-(4-(1-aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)piperidin-4-yl)-N-methylacetamide. The methods of the present invention can also relate to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing the above compounds in combination with ((R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine).

  本发明涉及利用3-(3-(4-(1-氨基环丁基)苯基)-5-苯基-3H-咪唑并[4,5-b]吡啶-2-基)吡啶-2-胺或3-(3-(4-(1-氨基环丁基)苯基)-5-(3-吗啉基苯基)-3H-咪唑并[4,5-b]吡啶-2-基)吡啶-2-胺或N-(1-(3-(3-(4-(1-氨基环丁基)苯基)-2-(2-氨基吡啶-3-基)-3H-咪唑并[4,5-b]吡啶-5-基)苯基)哌啶-4-基)-N-甲基乙酰胺等化合物治疗细胞增殖性疾病，如癌症或普罗特斯综合征的方法。本发明的方法还可以涉及利用上述化合物与((R)-6-(2-氟苯基)-N-(3-(2-((2-甲氧基乙基)氨基)乙基)苯基)-5,6-二氢苯并[h]喹唑啉-2-胺)结合治疗细胞增殖性疾病，如癌症或普罗特斯综合征的方法。
• Substituted Imidazopyridinyl-Aminopyridine Compounds
  申请人：Ashwell Mark A.

  公开号：US20120329791A1

  公开（公告）日：2012-12-27

  The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代咪唑吡啶基-氨基吡啶化合物及其合成方法。本发明还涉及含有取代咪唑吡啶基-氨基吡啶化合物的药物组合物，以及通过向需要的受试者投予这些化合物和药物组合物来治疗细胞增殖障碍，如癌症的方法。
• SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS
  申请人：ArQule, Inc.

  公开号：EP2723741A2

  公开（公告）日：2014-04-30
• COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS
  申请人：ArQule, Inc.

  公开号：EP3189036A1

  公开（公告）日：2017-07-12
• PHARMACEUTICAL COMBINATION FOR TREATMENT OF CANCER
  申请人：ArQule, Inc.

  公开号：US20200155521A1

  公开（公告）日：2020-05-21

  The present application is drawn to methods of treating a cell proliferative disorder, such as a cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising at least one of Compound 1, Compound 2, and Compound 3, or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, and at least one second therapeutic agent or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, wherein the cell proliferative disorder is treated.