4-Amino-1-cyclopropyl-4-piperidinecarbonitrile | 710350-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Amino-1-cyclopropyl-4-piperidinecarbonitrile
• 英文别名: 4-amino-1-cyclopropylpiperidine-4-carbonitrile
• CAS: 710350-69-9
• 化学式: C₉H₁₅N₃
• 分子量: 165.24
• InChiKey: KNCILBBJHCUXHG-UHFFFAOYSA-N

物化性质

• 沸点：
  292.2±40.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  53
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Cyanomethyl derivatives as cysteine protease inhibitors
  申请人：Graupe Michael

  公开号：US20060122184A1

  公开（公告）日：2006-06-08

  The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsin B, K, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及氰甲基衍生物，其是半胱氨酸蛋白酶的抑制剂，特别是对于B、K、F和S型的卡特普辛，因此可用于治疗由这些蛋白酶介导的疾病。本发明还涉及包含这些化合物的制药组合物和其制备过程。
• CYANOMETHYL DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS
  申请人：AXYS PHARMACEUTICALS, INC.

  公开号：EP1569954A1

  公开（公告）日：2005-09-07
• [EN] CYANOMETHYL DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS<br/>[FR] DERIVES DE CYANOMETHYLE EN TANT QU'INHIBITEURS DE LA PROTEASE A CYSTEINE
  申请人：AXYS PHARM INC

  公开号：WO2004052921A1

  公开（公告）日：2004-06-24

  The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.