2-fluoro-4-piperidin-4-ylbenzonitrile | 1035264-55-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-fluoro-4-piperidin-4-ylbenzonitrile
• 英文别名: 2-Fluoro-4-(piperidin-4-YL)benzonitrile
• CAS: 1035264-55-1
• 化学式: C₁₂H₁₃FN₂
• 分子量: 204.247
• InChiKey: JMVDBGDWWYQUJG-UHFFFAOYSA-N

物化性质

• 沸点：
  324.4±42.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Therapeutic Agents - 550
  申请人：Butlin Roger John

  公开号：US20090105305A1

  公开（公告）日：2009-04-23

  A compound of formula I or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as Fatty Acid Synthase inhibitors, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, cancer and infection and pharmaceutical compositions containing them.

  一种化学式I的化合物或其药学上可接受的盐，制备这种化合物的方法，其用作脂肪酸合成酶抑制剂，以及治疗肥胖症和糖尿病、癌症和感染的方法，以及包含它们的药物组合物。
• Antibacterial compounds
  申请人：Janssen Sciences Ireland UC

  公开号：US10364232B2

  公开（公告）日：2019-07-30

  The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.

  本发明涉及以下化合物 其中的整数如描述中所定义，这些化合物可用作药物，例如用于治疗结核病。
• Antibacterial Compounds
  申请人：Janssen Sciences Ireland UC

  公开号：US20180186768A1

  公开（公告）日：2018-07-05

  The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
• ANTIBACTERIAL COMPOUNDS
  申请人：Janssen Sciences Ireland UC

  公开号：US20190330189A1

  公开（公告）日：2019-10-31

  The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
• [EN] SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS<br/>[FR] DÉRIVÉS DE SULFONAMIDE À USAGE THÉRAPEUTIQUE EN TANT QU'INHIBITEURS DE SYNTHASE D'ACIDES GRAS
  申请人：ASTRAZENECA AB

  公开号：WO2008075070A1

  公开（公告）日：2008-06-26

  [EN] A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as Fatty Acid Synthase inhibitors, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, cancer and infection and pharmaceutical compositions containing them.
  [FR] L'invention concerne un composé de formule (I) ou un sel de celui-ci acceptable sur le plan pharmaceutique, des procédés de préparation de ces composés, leur utilisation en tant qu'inhibiteurs de synthase d'acides gras, des méthodes destinées à leur utilisation thérapeutique, notamment dans le traitement de l'obésité, du diabète sucré, du cancer et d'infections, et des compositions pharmaceutiques les contenant.