AZD-5153 enantiomer | 1869912-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: AZD-5153 enantiomer
• 英文别名: 4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
• CAS: 1869912-44-6
• 化学式: C₂₅H₃₃N₇O₃
• 分子量: 479.6
• InChiKey: RSMYFSPOTCDHHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES POUR UNE UTILISATION DANS LE TRAITEMENT DE MALADIES PROLIFÉRATIVES
  申请人：ASTRAZENECA AB

  公开号：WO2016016618A1

  公开（公告）日：2016-02-04

  The invention concerns compounds of Formula (I) (Formula (I)) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined herein before in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

  本发明涉及式(I)（式(I)）化合物或其药用可接受的盐，其中R1，R2和n具有在先前的描述中定义的任何含义；它们的制备过程，包含它们的药物组合物以及它们作为抗增殖和/或细胞杀伤剂的使用。
• [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：ASTRAZENECA AB

  公开号：US20170210747A1

  公开（公告）日：2017-07-27

  The invention concerns compounds of Formula (I) (Formula (I)) or pharmaceutically-acceptable salts thereof, wherein R 1 , R 2 and n have any of the meanings defined herein before in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

  本发明涉及化合物公式（I）（公式（I））或其药学上可接受的盐，其中R1、R2和n具有本描述中定义的任何含义；制备它们的过程，含有它们的制药组合物以及它们作为抗增殖和/或细胞杀伤剂的用途。
• [1,2,4]triazolo[4,3-B]pyridazines for use in the treatment of proliferative diseases
  申请人：AstraZeneca AB

  公开号：US10407432B2

  公开（公告）日：2019-09-10

  The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

  本发明涉及式（I）化合物 或其药学上可接受的盐，其中 R1、R2 和 n 具有本文在描述中定义的任何含义；它们的制备工艺、含有它们的药物组合物以及它们作为抗增殖剂和/或细胞杀伤剂的用途。
• 1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：AstraZeneca AB

  公开号：US20210107905A1

  公开（公告）日：2021-04-15

  The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R 1 , R 2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.
• US9944650B2
  申请人：——

  公开号：US9944650B2

  公开（公告）日：2018-04-17