3-methyl-3-azabicyclo[3.1.1]heptan-6-one | 1240526-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-methyl-3-azabicyclo[3.1.1]heptan-6-one
• CAS: 1240526-26-4
• 化学式: C₇H₁₁NO
• mdl: MFCD19442707
• 分子量: 125.17
• InChiKey: SAWKZFSKZRHOJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-methyl-6,6-dimethoxy-3-azabicyclo[3.1.1]heptane 在 三氟乙酸 作用下， 以92%的产率得到3-methyl-3-azabicyclo[3.1.1]heptan-6-one
  参考文献：
  名称：

  3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry

  摘要：

  An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.

  DOI：

  10.1021/ol101866x

文献信息

• Nitrogen-Containing Heterocyclyl Substituted Imidazoquinolines and Imidazonaphthyridines
  申请人：Merrill A. Bryon

  公开号：US20070213356A1

  公开（公告）日：2007-09-13

  Imidazoquinoline and imidazonaphthyridine compounds having a nitrogen-containing heterocyclyl substituent at the 5-, 6-, 7-, or 8-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本发明涉及在5-、6-、7-或8-位置具有含氮杂环基取代基的咪唑喹啉和咪唑萘啶化合物，含有这些化合物的制药组合物、中间体以及制备和使用这些化合物作为免疫调节剂、在动物中调节细胞因子生物合成以及用于治疗包括病毒性和肿瘤性疾病的方法。
• US8017779B2
  申请人：——

  公开号：US8017779B2

  公开（公告）日：2011-09-13
• [EN] COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES<br/>[FR] COMPOSÉS, SELS ASSOCIÉS ET MÉTHODES POUR LE TRAITEMENT DE MALADIES
  申请人：ACADIA PHARM INC

  公开号：WO2019040106A2

  公开（公告）日：2019-02-28

  The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.
• 3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: A Promising Building Block for Medicinal Chemistry
  作者：Aleksandr V. Denisenko、Andrey P. Mityuk、Oleksandr O. Grygorenko、Dmytro M. Volochnyuk、Oleg V. Shishkin、Andrey A. Tolmachev、Pavel K. Mykhailiuk

  DOI：10.1021/ol101866x

  日期：2010.10.1

  An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.