2-(1-benzylpiperidin-4-yl)-6-[(4-methylphenyl)sulfonyl]-2,4,5,6-tetrahydropyrazolo[3,4-d]pyrido[2,3-b]azepin-3-ol | 1246619-32-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(1-benzylpiperidin-4-yl)-6-[(4-methylphenyl)sulfonyl]-2,4,5,6-tetrahydropyrazolo[3,4-d]pyrido[2,3-b]azepin-3-ol
• CAS: 1246619-32-8
• 化学式: C₂₉H₃₁N₅O₃S
• 分子量: 529.663
• InChiKey: YTKBTEJXWYGIOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.55
• 重原子数：
  38.0
• 可旋转键数：
  5.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  91.56
• 氢给体数：
  1.0
• 氢受体数：
  7.0

文献信息

• SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS
  申请人：Lapierre Jean-Marc

  公开号：US20100249109A1

  公开（公告）日：2010-09-30

  The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的四氢吡唑-吡啶-氮杂环庚烷化合物及其合成方法。本发明还涉及含有取代的四氢吡唑-吡啶-氮杂环庚烷化合物的药物组合物，以及通过将这些化合物和药物组合物用于需要治疗细胞增殖性疾病，如癌症的受试者，来治疗这些疾病的方法。
• Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds
  申请人：Lapierre Jean-Marc

  公开号：US20120015935A1

  公开（公告）日：2012-01-19

  The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
• US8049005B2
  申请人：——

  公开号：US8049005B2

  公开（公告）日：2011-11-01
• US8293892B2
  申请人：——

  公开号：US8293892B2

  公开（公告）日：2012-10-23
• [EN] SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS<br/>[FR] COMPOSÉS TÉTRAHYDROPYRAZOLO-PYRIDO-AZÉPINE SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2010114902A1

  公开（公告）日：2010-10-07

  The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof, or a pharmaceutically acceptable salt or ester thereof, wherein: X1, X2; and X3, together with the two carbon atoms numbered "1" and "2", form a ring selected from (a), (b) and (c).