(2R,5R)-3-ethenylsulfonyl-5-methoxy-2-(trityloxymethyl)-2,5-dihydrofuran | 1238074-03-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2R,5R)-3-ethenylsulfonyl-5-methoxy-2-(trityloxymethyl)-2,5-dihydrofuran
• CAS: 1238074-03-7
• 化学式: C₂₇H₂₆O₅S
• 分子量: 462.566
• InChiKey: NPQLFHMBMXACAQ-AOYPEHQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2R,5R)-3-ethenylsulfonyl-5-methoxy-2-(trityloxymethyl)-2,5-dihydrofuran 、 苄胺 以 甲醇 为溶剂， 反应 6.0h， 以95%的产率得到
  参考文献：
  名称：

  First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates

  摘要：

  Divinyl sulfone-modified carbohydrates have been synthesized for the first time by reacting easily available carbohydrate epoxides with thioethanol in a regiospecific fashion. One of the modified divinyl sulfones initiated significant cell death in Entamoeba species and the influence of the anomeric configurations on the biological activities of these sugar-derived divinyl sulfones has been highlighted. The most active compound in this series was found to be devoid of any toxicity. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.04.056
• 作为产物：
  描述：

  在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以1.89 g的产率得到(2R,5R)-3-ethenylsulfonyl-5-methoxy-2-(trityloxymethyl)-2,5-dihydrofuran
  参考文献：
  名称：

  First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates

  摘要：

  Divinyl sulfone-modified carbohydrates have been synthesized for the first time by reacting easily available carbohydrate epoxides with thioethanol in a regiospecific fashion. One of the modified divinyl sulfones initiated significant cell death in Entamoeba species and the influence of the anomeric configurations on the biological activities of these sugar-derived divinyl sulfones has been highlighted. The most active compound in this series was found to be devoid of any toxicity. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.04.056

文献信息

• First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates
  作者：Tarun Kumar Pal、Tuli Dey、Arindam Chakrabarty、Debanjana Dey、Sudip K. Ghosh、Tanmaya Pathak

  DOI：10.1016/j.bmcl.2010.04.056

  日期：2010.6

  Divinyl sulfone-modified carbohydrates have been synthesized for the first time by reacting easily available carbohydrate epoxides with thioethanol in a regiospecific fashion. One of the modified divinyl sulfones initiated significant cell death in Entamoeba species and the influence of the anomeric configurations on the biological activities of these sugar-derived divinyl sulfones has been highlighted. The most active compound in this series was found to be devoid of any toxicity. (C) 2010 Published by Elsevier Ltd.