Methyl 2,2,6,6-tetramethyl-4-oxopiperidine-3-carboxylate | 1159977-55-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Methyl 2,2,6,6-tetramethyl-4-oxopiperidine-3-carboxylate
• CAS: 1159977-55-5
• 化学式: C₁₁H₁₉NO₃
• 分子量: 213.27
• InChiKey: FZQMQLOFIFWFQC-UHFFFAOYSA-N

物化性质

• 沸点：
  274.4±35.0 °C(Predicted)
• 密度：
  0.999±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿、二氯甲烷、乙酸乙酯、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME
  申请人：Trevena, Inc.

  公开号：EP4086249A2

  公开（公告）日：2022-11-09

  The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

  本发明的实施方案部分涉及用于调节δ阿片受体活性的化合物或其药学上可接受的盐，或其药物组合物，偏向和/或不偏向，和/或用于治疗疼痛、偏头痛、头痛、抑郁症、帕金森病、焦虑和/或膀胱过度活动症，以及本文所述的其他疾病和病症或其任意组合的方法。
• 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
  申请人：Trevena, Inc.

  公开号：US10246436B2

  公开（公告）日：2019-04-02

  The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

  本发明的实施方案部分涉及用于调节δ阿片受体活性的化合物或其药学上可接受的盐，或其药物组合物，偏向和/或不偏向，和/或用于治疗疼痛、偏头痛、头痛、抑郁症、帕金森病、焦虑和/或膀胱过度活动症，以及本文所述的其他疾病和病症或其任意组合的方法。
• [EN] 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME<br/>[FR] AZA-HÉTÉROCYCLIQUE À 6 ÉLÉMENTS CONTENANT DES COMPOSÉS MODULATEURS DE RÉCEPTEURS OPIOÏDES DELTA, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：TREVENA INC

  公开号：WO2017040545A1

  公开（公告）日：2017-03-09

  The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.